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Clustering of Brugia malayi infection in a community in South-Sulawesi, Indonesia

Published online by Cambridge University Press:  01 January 2000

A. J. TERHELL ,
J. J. HOUWING-DUISTERMAAT ,
Y. RUITERMAN ,
M. HAARBRINK ,
K. ABADI  and
M. YAZDANBAKHSH
A. J. TERHELL
Affiliation:
Department of Parasitology, Leiden University Medical Centre, PO Box 9605, 2300 RC, Leiden, The Netherlands
J. J. HOUWING-DUISTERMAAT
Affiliation:
Department of Medical Statistics, Leiden University, PO Box 9604, 2300 RC, Leiden, The Netherlands
Y. RUITERMAN
Affiliation:
Department of Parasitology, Leiden University Medical Centre, PO Box 9605, 2300 RC, Leiden, The Netherlands
M. HAARBRINK
Affiliation:
Department of Parasitology, Leiden University Medical Centre, PO Box 9605, 2300 RC, Leiden, The Netherlands
K. ABADI
Affiliation:
Department of Parasitology, Hasanuddin University, Kampus Tamalanrea, Jl. Perintis Kemerdekaan, Ujung Pandang, Sulawesi, Indonesia
M. YAZDANBAKHSH
Affiliation:
Department of Parasitology, Leiden University Medical Centre, PO Box 9605, 2300 RC, Leiden, The Netherlands
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Abstract

The present study was undertaken in village Karondang in South-Sulawesi, Indonesia, to investigate the influences of genetic, household and environmental factors on Brugia malayi infection. Infection status was determined by measuring both microfilariae in night blood and anti-filarial IgG4, as a marker for detection of active filarial infection. A total of 171 residents participated in the study; familial relationships between subjects were registered to construct pedigrees and distances between households were measured. The data were analysed using a test statistic for familial aggregation. For distribution of microfilariae over the study population a genetic influence on infection susceptibility was favoured over the household and environmental effects. For anti-filarial IgG4, all 3 clustering models gave significant results, suggesting that genetic, household and/or environmental factors influence specific IgG4 antibodies.

Keywords

lymphatic filariasisfamilieshouseholdsenvironmental clusteringmicrofilariaeIgG4
Type
Research Article
Information
Parasitology , Volume 120 , Issue 1 , January 2000 , pp. 23 - 29
Copyright
2000 Cambridge University Press

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