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The genomic Echinococcus microsatellite EmsB sequences: from a molecular marker to the epidemiological tool

Published online by Cambridge University Press:  22 December 2009

J. KNAPP ,
J. M. BART ,
S. MAILLARD ,
B. GOTTSTEIN  and
R. PIARROUX
J. KNAPP
Affiliation:
Laboratory of Chrono-Environment, Department of Parasitology, UMR CNRS 6249, usc INRA, University of Franche-Comté, 19 rue Ambroise Paré, 25030Besançon, France Institute of Parasitology, Vetsuisse Faculty, University of Bern, Längass-Strasse 122, 3012Bern, Switzerland
J. M. BART
Affiliation:
Laboratory of Chrono-Environment, Department of Parasitology, UMR CNRS 6249, usc INRA, University of Franche-Comté, 19 rue Ambroise Paré, 25030Besançon, France
S. MAILLARD
Affiliation:
Laboratory of Chrono-Environment, Department of Parasitology, UMR CNRS 6249, usc INRA, University of Franche-Comté, 19 rue Ambroise Paré, 25030Besançon, France Institute of Parasitology, Vetsuisse Faculty, University of Bern, Längass-Strasse 122, 3012Bern, Switzerland
B. GOTTSTEIN*
Affiliation:
Institute of Parasitology, Vetsuisse Faculty, University of Bern, Längass-Strasse 122, 3012Bern, Switzerland
R. PIARROUX
Affiliation:
Laboratory of Chrono-Environment, Department of Parasitology, UMR CNRS 6249, usc INRA, University of Franche-Comté, 19 rue Ambroise Paré, 25030Besançon, France Department of Parasitology and Mycology, Hôpital la Timone, 13005Marseille, France
*
*Corresponding author: Institute of Parasitology, Vetsuisse Faculty, University of Bern, Längass-Strasse 122, 3012Bern, Switzerland. Tel: +41(31)6312476. Fax: +41(31)6312622. E-mail: bruno.gottstein@ipa.unibe.ch
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Summary

In the field of molecular and epidemiological parasitology, characterization of fast evolving genetic markers appears as an important challenge to consider the diversity and genetic structure of parasites. The study of respective populations can help us to understand their adaptive strategies to survive and perpetuate the species within different host populations, all trying to resist infection. In the past, the relative monomorphic features of Echinococcus multilocularis, the causative agent of alveolar echinococcosis and a severe human parasitic disease, did not stimulate studies dealing with the genetic variability of Echinococcus species or respective populations. A recently developed, characterized and validated original multilocus microsatellite, named EmsB, tandemly repeated in the genome, offered an additional opportunity for this line of investigation. We have compiled in this review new insights brought by this molecular tracker on the transmission activity of Echinococcus among different hosts and at different geographical scales.

Keywords

Echinococcus multilocularishighly polymorphic molecular markermicrosatellite EmsBpopulation dynamic activitytransmission patterneco-epidemiology
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 3: Development and applications of cestode and trematode laboratory models , March 2010 , pp. 439 - 449
Copyright
Copyright © Cambridge University Press 2009

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