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The human anion transport protein, band 3, contains a CD36-like binding domain for Plasmodium falciparum-infected erythrocytes

Published online by Cambridge University Press:  06 April 2009

I. Crandall
Affiliation:
Department of Biology, University of California, Riverside, California 92521, USA
I. W. Sherman
Affiliation:
Department of Biology, University of California, Riverside, California 92521, USA

Summary

Epitope mapping of a murine monoclonal antibody (mAb), 5H12, prepared against live Plasmodium falciparum-intected red blood cells indicated that the epitope consisted of amino acid residues 474–487 of the human anion transport protein, band 3. mAb 5H12 enhanced cytoadherence, but inhibited the CD36-like mediated resetting. A synthetic peptide based on the sequence of the epitope (FSFCETNGLE) blocked both resetting and cytoadherence, suggesting that this amino acid sequence may form the CD36-like receptor. The CD36-like region of band 3 was antigenically distinct from platelet or endothelial CD36.

Type
Research Article
Copyright
Copyright © Cambridge University Press 1996

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