Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-15T03:22:59.977Z Has data issue: false hasContentIssue false
  • English
  • Français

Impairment of primary expulsion of Trichuris muris in mice concurrently infected with Nematospiroides dubius

Published online by Cambridge University Press:  06 April 2009

Simon N Jenkins  and
Jerzy M Behnke
Simon N Jenkins
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
Jerzy M Behnke
Affiliation:
Wellcome Laboratories for Experimental Parasitology, University of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
Get access Rights & Permissions [Opens in a new window]

Extract

Primary immune expulsion of Trichuris muris was markedly delayed by concurrent infection with Nematospiroides dubius. Maximum delay of expulsion was dependent on size and timing of N. dubius infection relative to T. muris infection. In NIH mice infection with 400 N. dubius larvae immediately before or after T. muris infection was found to be most effective in suppressing expulsion. Infection on day 8 of T. muris infection, when mice are sensitized to T. muris, also impaired expulsion. From this evidence it is suggested that the larvae of N. dubius are immunosuppressive and that the efferent role of the immune response to T. muris is inhibited. The results are discussed in terms of non-specific immunosuppression and their relevance to the tropical disease situation is emphasized.

Type
Research Article
Information
Parasitology , Volume 75 , Issue 1 , August 1977 , pp. 71 - 78
Copyright
Copyright © Cambridge University Press 1977

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bartlett, A. & Ball, P. A. J. (1972). Nematospiroides dubius in the mouse as a possible model of endemic human hookworm infection. Annals of Tropical Medicine and Parasitology 66, 129–34.CrossRefGoogle ScholarPubMed
Brown, A. R., Crandall, R. B. & Crandall, C. A. (1976). Increased IgG catabolism as a possible factor in the immunosuppression produced in mice infected with Nematospiroides dubius. Journal of Parasitology 62, 169–71.CrossRefGoogle Scholar
Bryant, V. (1973). The life-cycle of Nematospiroides dubius, Baylis, 1926 (Nematoda, Heligmosomidae). Journal of Helminthology 47, 263–8.CrossRefGoogle ScholarPubMed
Chowaniec, W., Wescott, R. B. & Congdon, L. L. (1972). Interaction of Nematospiroides dubius and influenza virus in mice. Experimental Parasitology 32, 33–44.CrossRefGoogle ScholarPubMed
Collwell, D. A. & Wescott, R. B. (1973). Prolongation of egg production of Nippostrongylus brasiliensis in mice concurrently infected with Nematospiroides dubius. Journal of Parasitology 59, 216.CrossRefGoogle Scholar
Ehrenford, F. A. (1954). The life-cycle of Nematospiroides dubius Baylis (Nematoda: Heligmosomidae). Journal of Parasitology 40, 480–1.CrossRefGoogle Scholar
Faubert, G. M. (1976). Depression of plaque forming cells to SRBC by the new-born larvae of Trichinella spiralis. Immunology 30, 485–90.Google Scholar
Jenkins, D. C. (1975). The influence of Nematospiroides dubius on subsequent Nippostrongylus brasiliensis infections in mice. Parasitology 71, 349–55.CrossRefGoogle ScholarPubMed
Shimp, R. G., Crandall, R. B. & Crandall, C. A. (1975). Heligmosomoides polygyrus (= Nematospiroides dubius): suppression of antibody response to orally administered sheep erythrocytes in infected mice. Experimental Parasitology 38, 257–69.CrossRefGoogle ScholarPubMed
Wakelin, D. (1967). Acquired immunity to Trichuris muris in the albino laboratory mouse. Parasitology 57, 515–24.CrossRefGoogle ScholarPubMed
Wakelin, D. (1975). Genetic control of immune responses to parasites: immunity to Trichuris muris in inbred and random-bred strains of mice. Parasitology 71, 51–60.CrossRefGoogle ScholarPubMed
Wakelin, D. & Lloyd, M. (1976). Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters. Parasitology 72, 173–82.CrossRefGoogle ScholarPubMed