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Metabolite-biomarker investigations in the life cycle of and infection with Schistosoma

Published online by Cambridge University Press:  16 June 2010

C. Legido-Quigley
C. Legido-Quigley*
Affiliation:
PSD, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
*
*Corresponding author: Tel: +44 2078484722. E-mail: cristina.legido_quigley@kcl.ac.uk
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Summary

Schistosome infection is endemic in many Third World countries and affects an estimated 200 million individuals. Over the last few years, a number of investigations have focused on small molecule biomarkers of this infection. These studies were aimed at discovering key molecules relating to the life cycle of the parasite or deciphering metabolic change in the host during infection. In this review these studies are further divided into targeted approaches to find compounds and fingerprinting techniques i.e. metabonomics. A species-specific metabolite or group of biomarkers of the infection have yet to be discovered. For this reason a critical discussion contrasting with established diagnostic methods and future prospects are also provided.

Keywords

Schistosomemetabolitesmetabonomics
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 9: Insights into the metabolomes of parasites , August 2010 , pp. 1425 - 1435
Copyright
Copyright © Cambridge University Press 2010

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