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Molecular forms of tegumental and muscle acetylcholinesterases of Schistosoma

Published online by Cambridge University Press:  26 March 2010

M. Camacho ,
S. Alsford  and
A. Agnew
M. Camacho
Affiliation:
Department of Biology, Imperial College of Science, Technology and Medicine, London, SW7 2BB
S. Alsford
Affiliation:
Department of Biology, Imperial College of Science, Technology and Medicine, London, SW7 2BB
A. Agnew
Affiliation:
Department of Biology, Imperial College of Science, Technology and Medicine, London, SW7 2BB
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Summary

Acetylcholinesterase (ACHE) is present in the muscle and on the tegument of schistosomes. Molecular forms of schistosome AChE were examined because particular AChEs are found in tissues of distinct function elsewhere. The dimeric globular form (G2) is the only form evident in adult Schistosoma haematobium: 32 % of the muscle AChE is hydrophilic and 61 % is membrane associated. A substantial amount of this enzyme is phosphatidylinositol (PI) anchored since it could be released by PI-specific phospholipase C from both muscle and tegumental membranes.

Keywords

S. haematobiumacetylcholinesteraseG2phosphatidylinositoltegumentmuscle
Type
Research Article
Information
Parasitology , Volume 112 , Issue 2 , February 1996 , pp. 199 - 204
Copyright
Copyright © Cambridge University Press 1996

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