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Polyclonal activation of B lymphocytes during experimental infection with Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009

L. M. Lopes ,
M. A. C. Pereira ,
S. E. Gerken  and
N. Vaz
L. M. Lopes
Affiliation:
Department of Biochemistry and Immunology, Instituto de Ciências Biolódgicas, Universidade Federal de Minas Gerais, 31270 Belo Horizonte, MG, Brasil
M. A. C. Pereira
Affiliation:
Department of Biochemistry and Immunology, Instituto de Ciências Biolódgicas, Universidade Federal de Minas Gerais, 31270 Belo Horizonte, MG, Brasil
S. E. Gerken
Affiliation:
Department of Biochemistry and Immunology, Instituto de Ciências Biolódgicas, Universidade Federal de Minas Gerais, 31270 Belo Horizonte, MG, Brasil
N. Vaz
Affiliation:
Department of Biochemistry and Immunology, Instituto de Ciências Biolódgicas, Universidade Federal de Minas Gerais, 31270 Belo Horizonte, MG, Brasil
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Summary

A significant polyclonal activation of B lymphocytes was observed during experimental infection of C57BL/10J mice with Schistosoma mansoni. The isotypic pattern of this expansion, assessed by the Protein-A plaque-forming cell method, was compared with and found to differ from those occurring after infection by Trypanosoma cruzi or injection of bacterial LPS. In the infection of S. mansoni an early expansion of most immunoglobulin isotypes occurs together with a late, sustained expansion of IgG1-secreting cells. High levels of polyclonal B cell activation were observed after adoptive transfer of spleen cells from infected mice to isogenic recipients pre-treated with hydroxyurea.

Keywords

Schistosoma mansonipolyclonal activationIgG1hydroxyurea
Type
Research Article
Information
Parasitology , Volume 100 , Issue 1 , February 1990 , pp. 83 - 91
Copyright
Copyright © Cambridge University Press 1990

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