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Reversal of hypoglycaemia in murine malaria by drugs that inhibit insulin secretion

Published online by Cambridge University Press:  06 April 2009

K. M. Elased  and
J. H. L. Playfair
K. M. Elased
Affiliation:
Department of Immunology, UCL Medical School, Arthur Stanley House, Tottenham Street, London W1P 9PG, UK
J. H. L. Playfair*
Affiliation:
Department of Immunology, UCL Medical School, Arthur Stanley House, Tottenham Street, London W1P 9PG, UK
*
* Corresponding author. Tel: 0171 380 9349. Fax: 0171 380 9357.
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Summary

We have investigated the metabolic disturbances in 2 murine models of blood-stage malaria, Plasmodium chabaudi and Plasmodium yoelii. Blood glucose, plasma insulin and parasitaemia were measured in normal and infected mice before and after treatment with diazoxide, adrenaline, Sandostatin and quinine. Severe hypoglycaemia and marked hypersinsulinaemia developed during both infections. A single injection of diazoxide (25 mg/kg i.p.) or adrenaline (0·03 mg s.c.) lowered insulin concentrations in normal mice, reversed the hypoglycaemia in both infections and significantly reduced the hyperinsulinaemia in P. chabaudi-infected mice (P < 0·0001). Higher doses of Sandostatin (500 μg/kg s.c.) were required to reverse hypoglycaemia. Quinine (25 mg/kg i.p.) significantly increased blood glucose in normal and infected mice (P < 0·001) and no hypoglycaemia was observed in mice with normal blood glucose for more than 3 h. This study shows that the major cause of hypoglycaemia in murine malaria is hyperinsulinaemia rather than high consumption of glucose by host and parasites or chemotherapy with quinine, and that hypoglycaemia can be reversed by correcting the hyperinsulinaemia.

Keywords

malariainsulinhypoglycaemiadiazoxideSandostatinadrenaline
Type
Research Article
Information
Parasitology , Volume 112 , Issue 6 , June 1996 , pp. 515 - 521
Copyright
Copyright © Cambridge University Press 1996

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