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Taenia solium: current understanding of laboratory animal models of taeniosis

Published online by Cambridge University Press:  01 March 2010

A. FLISSER ,
G. ÁVILA ,
P. MARAVILLA ,
F. MENDLOVIC ,
S. LEÓN-CABRERA ,
M. CRUZ-RIVERA ,
A. GARZA ,
B. GÓMEZ ,
L. AGUILAR  and
N. TERÁN
...Show all authors
A. FLISSER*
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
G. ÁVILA
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
P. MARAVILLA
Affiliation:
Departamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González” Secretaría de Salud, Calzada de Tlalpan 4800, México14080 DF.
F. MENDLOVIC
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF. Escuela de Ciencias de la Salud, Universidad Anáhuac, México Norte, Av. Universidad Anáhuac 46, Huixquilucan, 52786. Estado de México
S. LEÓN-CABRERA
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
M. CRUZ-RIVERA
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
A. GARZA
Affiliation:
Departamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González” Secretaría de Salud, Calzada de Tlalpan 4800, México14080 DF.
B. GÓMEZ
Affiliation:
Departamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González” Secretaría de Salud, Calzada de Tlalpan 4800, México14080 DF.
L. AGUILAR
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
N. TERÁN
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
S. VELASCO
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
M. BENÍTEZ
Affiliation:
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF.
D. E. JIMENEZ-GONZALEZ
Affiliation:
Departamento de Ecología de Agentes Patógenos, Hospital General “Dr. Manuel Gea González” Secretaría de Salud, Calzada de Tlalpan 4800, México14080 DF.
*
*Corresponding author. Ana Flisser, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM), Av. Universidad 3000, México04510 DF, telephone: 5255-56232466, fax: 5255-56232382, e-mail: flisser@servidor.unam.mx
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Summary

Neurocysticercosis is a public health problem in many developing countries and is the most frequent parasitic disease of the brain. The human tapeworm carrier is the main risk factor for acquiring neurocysticercosis. Since the parasite lodges only in the human intestine, experimental models of Taenia solium taeniosis have been explored. Macaques, pigs, dogs, cats and rabbits are unsuccessful hosts even in immunodepressed status. By contrast, rodents are adequate hosts since tapeworms with mature, pregravid and, in some cases, gravid proglottids develop after infection. In this review, information that has been generated with experimental models of taeniosis due to T. solium is discussed. Initially, the use of the model for immunodiagnosis of human taeniosis and evaluation of intervention measures is summarized. Next, descriptions of tapeworms and comparison of hamsters, gerbils and other mammals as experimental models are discussed, as well as data on the humoral immune response, the inflammatory reaction and the production of cytokines associated to Th1 and Th2 responses in the intestinal mucosa. Finally, evaluation of protection induced against the development of tapeworms by recombinant T. solium calreticulin in hamsters is summarized and compared to other studies.

Keywords

Chinchillascysticercosiscytokinesexperimental modelsgerbilshamstersimmune responseinflammatory cellsintestinal mucosaTaenia soliumtaeniosisvaccines
Type
Research Article
Information
Parasitology , Volume 137 , Special Issue 3: Development and applications of cestode and trematode laboratory models , March 2010 , pp. 347 - 357
Copyright
Copyright © Cambridge University Press 2010

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