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Seasonal changes in the Plasmodium falciparum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village

Published online by Cambridge University Press:  01 June 1998

C. ROPER ,
W. RICHARDSON ,
I. M. ELHASSAN ,
H. GIHA ,
L. HVIID ,
G. M. H. SATTI ,
T. G. THEANDER  and
D. E. ARNOT
C. ROPER
Affiliation:
Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK Present address: Department of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
W. RICHARDSON
Affiliation:
Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
I. M. ELHASSAN
Affiliation:
Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
H. GIHA
Affiliation:
Centre for Medical Parasitology, Department of Infectious Diseases, National University Hospital (Rigshospitalet), Tagensvej 20, DK 2200 Copenhagen N, Denmark Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan Institute for Medical Microbiology and Immunology, Panum Institute 24-2, University of Copenhagen, Blegdamsveg 3, 2200 Copenhagen N, Denmark
L. HVIID
Affiliation:
Institute for Medical Microbiology and Immunology, Panum Institute 24-2, University of Copenhagen, Blegdamsveg 3, 2200 Copenhagen N, Denmark
G. M. H. SATTI
Affiliation:
Department of Biochemistry, Faculty of Medicine, University of Khartoum, Khartoum, Sudan
T. G. THEANDER
Affiliation:
Centre for Medical Parasitology, Department of Infectious Diseases, National University Hospital (Rigshospitalet), Tagensvej 20, DK 2200 Copenhagen N, Denmark
D. E. ARNOT
Affiliation:
Institute of Cell, Animal and Population Biology, Division of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
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Abstract

Residents of Daraweesh village in Sudan were monitored for Plasmodium falciparum infection and malaria morbidity in 3 malaria seasons from 1993 to 1996. Malaria parasites were detected microscopically and by polymerase chain reaction (PCR) in a series of cross-sectional surveys. PCR revealed submicroscopical infections during the dry season, particularly among individuals who had recovered from a malaria episode following successful drug treatment. Clinical and subclinical infections were contrasted by assaying for allelic polymorphism at 2 gene loci, MSP-1 and GLURP and 2 hypotheses examined with reference to these data: that clinical malaria is associated with infection with novel parasite genotypes not previously detected in that host, or alternatively, that clinical malaria episodes are associated with an increased number of clones in an infection. We detected more mixed infections among clinical isolates, but people carrying parasites during the dry season were not found to have an increased risk of disease in the following malaria season. There was a clear association of disease with the appearance of novel parasite genotypes.

Keywords

Plasmodium falciparumasymptomatic infectionPCR genotypinglongitudinal field studiesSudan
Type
Research Article
Information
Parasitology , Volume 116 , Issue 6 , June 1998 , pp. 501 - 510
Copyright
1998 Cambridge University Press

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