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Toxoplasma gondii Hsp90: potential roles in essential cellular processes of the parasite

Published online by Cambridge University Press:  21 February 2014

SERGIO O. ANGEL ,
MARIA J. FIGUERAS ,
MARIA L. ALOMAR ,
PABLO C. ECHEVERRIA  and
BIN DENG
SERGIO O. ANGEL*
Affiliation:
Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET-UNSAM, Av. Intendente Marino Km. 8·2, C.C 164, (B7130IIWA), Chascomús, Prov. Buenos Aires, Argentina
MARIA J. FIGUERAS
Affiliation:
Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET-UNSAM, Av. Intendente Marino Km. 8·2, C.C 164, (B7130IIWA), Chascomús, Prov. Buenos Aires, Argentina
MARIA L. ALOMAR
Affiliation:
Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET-UNSAM, Av. Intendente Marino Km. 8·2, C.C 164, (B7130IIWA), Chascomús, Prov. Buenos Aires, Argentina
PABLO C. ECHEVERRIA
Affiliation:
Département de Biologie Cellulaire Université de Genève Sciences III, Geneva, Switzerland
BIN DENG
Affiliation:
Biology Department, Vermont Genetics Network Proteomics Facility, The University of Vermont, 337 marsh Life Science Building, 109 Carrigan Drive, Burlington, VT 05405, USA
*
*Corresponding author. Laboratorio de Parasitología Molecular, IIB-INTECH, CONICET-UNSAM, Av. Intendente Marino Km. 8·2, C.C 164, (B7130IIWA), Chascomús, Prov. Buenos Aires, Argentina. E-mail: sangel@intech.gov.ar
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Summary

Hsp90 is a widely distributed and highly conserved molecular chaperone that is ubiquitously expressed throughout nature, being one of the most abundant proteins within non-stressed cells. This chaperone is up-regulated following stressful events and has been involved in many cellular processes. In Toxoplasma gondii, Hsp90 could be linked with many essential processes of the parasite such as host cell invasion, replication and tachyzoite-bradyzoite interconversion. A Protein-Protein Interaction (PPI) network approach of TgHsp90 has allowed inferring how these processes may be altered. In addition, data mining of T. gondii phosphoproteome and acetylome has allowed the generation of the phosphorylation and acetylation map of TgHsp90. This review focuses on the potential roles of TgHsp90 in parasite biology and the analysis of experimental data in comparison with its counterparts in yeast and humans.

Keywords

Toxoplasma gondiiHsp90cell cyclepost-translational modificationdevelopment
Type
Special Issue Article
Information
Parasitology , Volume 141 , Special Issue 9: Heat shock proteins as drug targets in infectious diseases , August 2014 , pp. 1138 - 1147
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Copyright
Copyright © Cambridge University Press 2014 

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