The last decade observations revealed the essential variations of energy balance take place in the pre-flare active regions at all atmospheric levels and they are caused by both evolution of AR and processes associated with flare activity. We present the multi-wavelength study of the solar flare jointly with the preceding event. The combined investigation is perspective for the mechanism understanding of the energy storage, trigger and release during the solar flares. A special attention was given to signatures of energetic particle beam effect on chromosphere according to H$\alpha$ and CaII K intensity changes. Combination of data from ground based instruments and space observatories (TRACE, MDI, RHESSI) will allow us to track processes taking place in a wide range of solar atmosphere layers - from the temperature minimum region to the corona. The obtained results are discussed.