We performed three-dimensional hydrodynamical simulations of idealized giant molecular cloud collisions including star formation and radiative transfer. We found that the characteristics of the colliding systems are similar to the observations of the Spitzer bubbles, suggesting these objects could be created in such interactions. A high velocity collision creates a top-heavy core mass distribution but is not strongly affected by radiation. At lower collision speeds, the HII regions have time to expand within the shock and promote the formation of massive cores.