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Adipocyte hormone-sensitive lipase: a major regulator of lipid metabolism

Published online by Cambridge University Press:  11 October 2007

Dominique Langin
Affiliation:
Unité INSERM 317, Institut Louis Bugnard, Faculté de Médecine, Université Paul Sabatier, CHR Rangueil, Bât. L3, 31054, Toulouse Cedex, France
Cecilia Holm
Affiliation:
Section for Molecular Signalling, Department of Cell and Molecular Biology, Lund University, PO Box 94, 221 00, Lund, Sweden
Max Lafontan
Affiliation:
Unité INSERM 317, Institut Louis Bugnard, Faculté de Médecine, Université Paul Sabatier, CHR Rangueil, Bât. L3, 31054, Toulouse Cedex, France
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Abstract

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Type
Principal Symposium on ‘Lipid absorption and metabolism: physiological and molecular aspects’
Copyright
Copyright © The Nutrition Society 1996

References

Ailhaud, G., Grimaldi, P. & Négrel, R. (1992). Cellular and molecular aspects of adipose tissue development. Annual Review of Nutrition 12, 207233.CrossRefGoogle ScholarPubMed
Au-Young, J. & Fielding, C. J. (1992). Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-termina region is required for both lipoprotein binding and catalysis of transfer. Proceedings of the National Academy of Sciences, USA 89, 40944098.CrossRefGoogle ScholarPubMed
Berlan, M. & Lafontan, M. (1985). Evidence that epinephrine acts preferentially as an antilipolytic asent in abdominal human subcutaneous fat cells: assessment by analysis of beta-and alpha-2-adrenoceptors properties. European Journal of Clinical Investigation 15, 341346.CrossRefGoogle Scholar
Björntorp, P. (1990). ‘Portal’ adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 10, 493496.CrossRefGoogle Scholar
Chowdhary, B. P., Thomsen, P. D., Harbitz, I., Landset, M. & Gustavsson, I. (1994). Precise localization of the genes for glucose phosphate isomerase (GPI), calcium release channel (CRC), hormone-sensitive lipase (LIPE), and growth hormone (GH) in pigs, using nonradioactive in situ hybridization. Cytogenetics and Cell Genetics 67, 211214.CrossRefGoogle ScholarPubMed
Corton, J., Gillespie, J., Hawley, S. & Hardie, D. (1995). 5-Aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?. European Journal of Biochemistry 229, 558565.CrossRefGoogle ScholarPubMed
Degerman, E., Smith, C. J., Tornquist, H., Vasta, V., Belfrage, P. & Manganiello, V. C. (1990). Evidence that insulin and isoprenaline activate the cGMP-inhibited low Km cAMP-phosphodiesterase in rat fat cells by phosphorylation. Proceedings of the National Academy of Sciences, USA 87, 533537.CrossRefGoogle Scholar
Derewenda, Z. S. (1994). Structure and function of lipases. Advances in Protein Chemistry 45, 152.CrossRefGoogle ScholarPubMed
Egan, J. J., Greenberg, A. S., Chang, M.-K., Wek, S. A., Moos, M. C. Jr & Londos, C. (1992). Mechanism of hormone-stimulated lipolysis in adipocytes: Translocation of hormone-sensitive lipase to the lipid storage droplet. Proceedings of the National Academy of Sciences, USA 89, 85378541.CrossRefGoogle Scholar
Eriksson, H., Ridderstrale, M., Degerman, E., Ekholm, D., Smith, C. J., Manganiello, V. C., Belfrage, P. & Tornqvist, H. (1995). Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin. Biochimica et Biophysica Acta 1266, 101107.CrossRefGoogle ScholarPubMed
Fain, J. N., Garcia-Sainz, J. A. (1983). Adrenergic regulation of adipocyte metabolism. Journal of Lipid Research 24, 945966.CrossRefGoogle ScholarPubMed
Frayn, K. & Coppack, S. (1993). Insulin resistance, adipose tissue and coronary heart disease. Clinical Science 82, 18.CrossRefGoogle Scholar
Frayn, K. N., Coppack, S. W., Fielding, B. A. & Humphreys, S. M. (1995). Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Advances in Enzyme Regulation 35, 163178.CrossRefGoogle ScholarPubMed
Frayn, K. N., Langin, D., Holm, C. & Belfrage, P. (1993). Hormone-sensitive lipase: quantitation of enzyme activity and mRNA level in small biopsies of human adipose tissue. Clinica Chimica Acta 216, 183189.CrossRefGoogle ScholarPubMed
Fredrikson, G., Tornqvist, H. & Belfrage, P. (1986). Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Biochimica et Biophysica Acta 876, 288293.CrossRefGoogle ScholarPubMed
Fujii, J., Otsu, K., Zorzato, F., De Leon, S., Khanna, V. K., Weiler, J. E., O'Brien, P. J. & MacLennan, D. H. (1991). Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science 253, 448451.CrossRefGoogle ScholarPubMed
Garton, A. J., Campbell, D. G., Carling, D., Hardie, D. G., Colbran, R. J. & Yeaman, S. J. (1989). Phosphorylation of bovine hormone-sensitive lipase by the AMP-activated protein kinase. A possible antilipolytic mechanism. European Journal of Biochemistry 179, 249254.CrossRefGoogle ScholarPubMed
Garton, A. J. & Yeaman, S. J. (1990). Identification and role of the basal phosphorylation site on hormone-sensitive iipase. European Journal of Biochemistry 191, 245250.CrossRefGoogle Scholar
Gettys, T. W., Rohlfs, E. M., Prpic, V., Daniel, K. W., Taylor, I. L. & Collins, S. (1995). Age-dependent changes in β-adre'nergic receptor subtypes and adenylyl cyclase activation in adipocytes from Fischer 344 rats. Endocrinology 136, 20222032.CrossRefGoogle ScholarPubMed
Greenberg, A., Egan, J. J., Wek, S. A., Garty, N. B., Blanchette-Mackie, E. J. & Londos, C. (1991). Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. Journal of Biological Chemistry 266, 1134111346.CrossRefGoogle Scholar
Greenberg, A. S., Egan, J. J., Wek, S. A., Moos, M. C. Jr, Londos, C. & Kimmel, A. R. (1993). Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes. Proceedings of the National Academy of Sciences, USA 90, 1203512039.CrossRefGoogle Scholar
Gu, F., Harbitz, I., Chowdhary, B. P., Bosnes, M. & Gustavsson, I. (1992). Chromosomal localization of the hormone sensitive lipase (LIPE) and insulin receptor (INSR) genes in pigs. Hereditas 117, 231236.CrossRefGoogle ScholarPubMed
Hardie, D. & McIntosh, R. (1992). AMP-activated protein kinase: an archetypal protein kinase cascade. BioEssays 14, 699704.CrossRefGoogle ScholarPubMed
Hare, J. F., Taylor, K. & Holocher, A. (1994). Energy-dependent protein-triacylglycerol interaction in a cell-free system from 3T3-L1 adipocytes. Journal of Biological Chemistry 269, 771776.CrossRefGoogle Scholar
Hemilä, H., Koivula, T. T. & Palva, I. (1994). Hormone-sensitive lipase is closely related to several bacterial proteins, and distantly related to acetylcholinesterase and protein lipase: identification of a superfamily of esterases and lipases. Biochimica et Biophysica Acta 1210, 249253.CrossRefGoogle ScholarPubMed
Hirsch, A. H. & Rosen, O. M. (1984). Lipolytic stimulation modulates the subcellular distribution of hormone-sensitive lipase in 3T3-L1 cells. Journal of Lipid Research 25, 665677.CrossRefGoogle Scholar
Holm, C., Belfrage, P. & Fredrikson, G. (1987). Immunological evidence for the presence of hormone-sensitive lipase in rat tissues other than adipose tissue. Biochemical and Biophysical Research Communications 148, 99105.CrossRefGoogle ScholarPubMed
Holm, C., Belfrage, P., Østerlund, T., Davis, R. C., Schotz, M. C. & Langin, D. (1994). Hormone-sensitive lipase: structure, function, evolution and overproduction in insect cells using the baculovirus expression system. Protein Engineering 7, 537541.CrossRefGoogle ScholarPubMed
Holm, C., Davis, R. C., Østerlund, T., Schotz, M. C. & Fredrikson, G. (1994). Identification of the active serine of hormone-sensitive lipase by site-directed mutagenesis. FEBS Letters 344, 234238.CrossRefGoogle ScholarPubMed
Holm, C., Fredrikson, G. & Belfrage, P. (1986). Demonstration of the amphiphilic character of hormone-sensitive lipase by temperature-induced phase separation in triton X-114 and charge-shift electrophoresis. Journal of Biological Chemistry 261, 1565915661.CrossRefGoogle ScholarPubMed
Holm, C., Kirchgessner, T. G., Svensson, K. L., Fredrikson, G., Nilsson, S., Miller, C. G., Shively, J. E., Heinzmann, C., Sparkes, R. S., Mohandas, T., Lusis, A. J., Belfrage, P. & Schotz, M. C. (1988). Hormone-sensitive lipase: sequence, expression and chromosomal localization to 19 cent q13.3. Science 241, 15031506.CrossRefGoogle Scholar
Honnor, R. C., Dhillon, G. S. & Londos, C. (1985). cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators. Journal of Biological Chemistry 260, 1513015138.CrossRefGoogle ScholarPubMed
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L. & Spiegelman, B. M. (1995). Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance. Journal of Clinical Investigation 95, 24092415.CrossRefGoogle ScholarPubMed
Jedlicka, A. E., Taylor, E. W., Meyers, D. A., Liu, Z. & Levitt, R. C. (1994). Localization of the highly polymorphic locus D19S120 to 19pl3.3 by linkage. Cytogenetics and Cell Genetics 65, 140.CrossRefGoogle ScholarPubMed
Jepson, C. A. & Yeaman, S. J. (1992). Inhibition of hormone-sensitive lipase by intermediary lipid metabolites. FEBS Letters 310, 197200.CrossRefGoogle ScholarPubMed
Kawakami, M., Murase, T., Igawa, H., Ishibashi, S., Mori, N., Takagu, F. & Shibata, S. (1987). Human recombinant TNF suppresses lipoprotein lipase activity and stimulates lipolysis in 3T3-L1 cells. Journal of Biochemistry 101, 331338.CrossRefGoogle Scholar
Kawamura, M., Jensen, D. F., Wancewicz, E. V., Joy, L. L., Khoo, J. C. & Steinberg, D. (1981). Hormone-sensitive lipase in differentiated 3T3-L1 cells and its activation by cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences, USA 78, 732736.CrossRefGoogle ScholarPubMed
Kern, P. A., Saghizadeh, M., Ong, J. M., Bosch, R. J., Deem, R. & Simsolo, R. B. (1995). The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation 95, 21112119.CrossRefGoogle ScholarPubMed
Kraemer, F., Patel, S., Saedi, M. & Sztalryd, C. (1993). Detection of hormone-sensitive lipase in various tissues. I. Expression of an HSL/bacterial fusion protein and generation of anti-HSL antibodies. Journal of Lipid Research 34, 663671.CrossRefGoogle ScholarPubMed
Kraemer, F. B., Tavanger, K. & Hoffman, A. R. (1991). Developmental regulation of hormone-sensitive lipase mRNA in the rat: changes in steroidogenic tissues. Journal of Lipid Research 32, 1503–1310.CrossRefGoogle ScholarPubMed
Lafontan, M. & Berlan, M. (1993). Fat cell adrenergic receptors and the control of white and brown fat cell function. Journal of Lipid Research 34, 10571091.CrossRefGoogle ScholarPubMed
Lafontan, M. & Langin, D. (1995). Cellular aspects of fuel mobilization and selection in white adipocytes. Proceedings of the Nutrition Society 54, 4963.CrossRefGoogle ScholarPubMed
Langin, D. & Holm, C. (1993). Sequence similarities between hormone-sensitive lipase and five prokaryotic enzymes. Trends in Biochemical Sciences 18, 466467.CrossRefGoogle ScholarPubMed
Langin, D., Laurell, H., Holst, L. S., Belfrage, P. & Holm, C. (1993). Gene organization and primary structure of human hormone-sensitive lipase: possible significance of a sequence homology with a lipase of Moraxella TA144, an antarctic bacterium. Proceedings of the National Academy of Sciences, USA 90, 48974901.CrossRefGoogle ScholarPubMed
Laurell, H., Grober, J., Hoist, L. S., Holm, C., Mohrenwieser, H. & Langin, D. (1995). The hormone-sensitive lipase (LIPE) gene located on chromosome 19q13.1–13.2 is not duplicated on 19p33.3. International Journal of Obesity 19, 590592.Google ScholarPubMed
Levitt, R. C., Jedlicka, A. E. & Nouri, N. (1992). Dinucleotide repeat polymorphism at the hormone sensitive lipase (LIPE) locus. Human Molecular Genetics 1, 139.CrossRefGoogle ScholarPubMed
Levitt, R. C., McKusick, V. A., Fletcher, J. E. & Rosenberg, H. (1990). Gene candidate. Nature 345, 297298.CrossRefGoogle ScholarPubMed
Levitt, R., Liu, Z., Nouri, N., Meyers, D., Brandriff, B. & Mohrenwieser, H. (1995). Mapping of the gene for hormone-sensitive lipase (LIPE) to chromosome 19q13.1–13.2. Cytogenetics and Cell Genetics 69, 211214.CrossRefGoogle Scholar
Li, Z., Sumida, M., Birchbauer, A., Schotz, M. C. & Reue, K. (1994). Isolation and characterization of the gene for mouse hormone-sensitive lipase. Gcnomics 24, 259265.CrossRefGoogle ScholarPubMed
Lönnqvist, F., Nyberg, B., Wahrenberg, H. & Arner, P. (1990). Catecholamine-induced lipolysis in adipose tissue of the elderly. Journal of Clinical Investigation 85, 16141621.CrossRefGoogle ScholarPubMed
Lopez-Aparicio, P., Belfrage, P., Manganiello, V. C., Kono, T. & Degerman, E. (1993). Stimulation by insulin of the serine kinase in human platelets that phosphorylates and activates the cGMP-inhibited cAMP phosphodiesterase. Biochemical and Biophysical Research Communications 193, 11371144.CrossRefGoogle ScholarPubMed
Manganiello, V. C., Degerman, E., Smith, C. J., Vasta, V., Tornqvist, H. & Belfrage, P. (1992). Mechanisms for activation of the rat adipocyte particulate cyclic-GMP-inhibited cyclic AMP phosphodiesterase and its importance in the antilipolytic action of insulin. In Advances in Second Messenger and Phosphoprotein Research Strada, S. J. & Hidaka, H. New York: Raven Press Ltd..Google Scholar
Martin-Hidalgo, A., Holm, C., Belfrage, P., Schotz, M. C. & Herrera, E. (1994). Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. American Journal of Physiology 266, E930E935.Google ScholarPubMed
Mauriège, P., Galitzky, J., Berlan, M. & Lafontan, M. (1987). Heterogeneous distribution of beta- and alpha-2-adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences. European Journal of Clinical Investigation 17, 156165.CrossRefGoogle ScholarPubMed
Olsson, H. & Belfrage, P. (1988). Phosphorylation and dephosphorylation of hormone-sensitive lipase. Interactions between the regulatory and basal phosphorylation sites. FEBS Letters 232, 7882.CrossRefGoogle ScholarPubMed
Patton, J., Shepard, H., Wilking, H., Lewis, G., Aggarwal, B., Eessalu, T., Gavin, L. & Grunfeld, C. (1986). Interferons and tumor necrosis factors have similar catabolic effects on 3T3 LI cells. Proceedings of the National Academy of Sciences, USA 83, 83138317.CrossRefGoogle Scholar
Probst, M. R., Beer, M., Beer, D., Jenö, P., Meyer, U. A. & Gasser, R. (1994). Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase. Journal of Biological Chemistry 269, 2165021656.CrossRefGoogle ScholarPubMed
Reaven, G. (1988). Role of insulin resistance in human disease. Diabetes 37, 15951607.CrossRefGoogle ScholarPubMed
Reynisdottir, S., Ellerfeldt, K., Wahrenberg, H., Lithell, H. & Arner, P. (1994). Multiple lipolysis defects in the insulin resistance (metabolic) syndrome. Journal of Clinical Investigation 93, 25902599.CrossRefGoogle ScholarPubMed
Reynisdottir, S., Eriksson, M., Angelin, B. & Arner, P. (1995a). Impaired activation of adipocyte lipolysis in familia combined hyperlipidemia. Journal of Clinical Investigation 95, 21612169.CrossRefGoogle Scholar
Reynisdottir, S., Langin, D., Carlström, K., Holm, C., Rössner, S. & Arner, P. (1995b). Effects of weight reduction on the regulation of lipolysis in adipocytes of women with upper-body obesity. Clinical Science 89, 421429.CrossRefGoogle ScholarPubMed
Ron, D., Brasier, A. R., McGehee, R. E. & Habener, J. F. (1992). Tumor necrosis factor-induced reversal of adipocyte phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). Journal of Clinical Investigation 89, 223233.CrossRefGoogle ScholarPubMed
Schonk, D., Van Dijk, P., Riegmann, P., Trapman, J., Holm, C., Willcocks, T. C., Sillekens, P., Van Venrooij, W., Wimmer, E., Van Kessel, A. G., Ropers, H. H. & Wieringa, B. (1990). Assignment of seven genes to distinct intervals on the midportion of human chromosome 19q surrounding the myotonic dystrophy gene region. Cytogenetics and Cell Genetics 54, 1519.CrossRefGoogle ScholarPubMed
Slavin, B. G., Ong, J. M. & Kern, P. A. (1994). Hormonal regulation of hormone-sensitive lipase activity and mRNA levels in isolated rat adipocytes. Journal of Lipid Research 35, 15351541.CrossRefGoogle ScholarPubMed
Smith, C. & Manganiello, V. (1988). Role of hormone-sensitive low Km cAMP phosphodiesterase in regulation of cAMP-dependent protein kinase and lipolysis in rat adipocytes. Molecular Pharmacology 35, 381386.Google Scholar
Smith, C. J., Vasta, V., Degerman, E., Belfrage, P. & Manganiello, V. C. (1991). Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation. Journal of Biological Chemistry 266, 1338513390.CrossRefGoogle ScholarPubMed
Spieaelman, B. M. & Hotamisligil, G. S. (1993). Through thick and thin: wasting, obesity, and TNFα. Cell 73, 625627.CrossRefGoogle Scholar
Strålfors, P. & Belfrage, P. (1983). Phosphorylation of hormone-sensitive iipase by cyclic AMP-dependent protein kinase. Journal of Biological Chemistry 258, 1514615152.CrossRefGoogle ScholarPubMed
Stråltors, P., Olsson, H. & Belfrage, P. (1987). Hormone-sensitive lipase. In The Enzymes 147177 Boyer, P. D., Kreb-, E. G. New York: Academic Press.Google Scholar
Sullivan, J. E., Brocklehurst, K. J., Marley, A. E., Carey, F., Carling, D. & Beri, R. K. (1994). Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Letters 353, 3336.CrossRefGoogle ScholarPubMed
Sumida, M., Sekiya, K., Okuda, H., Tanaka, Y. & Shiosaka, T. (1990). Inhibitory effect of tumor necrosis factor on gene expression of hormone sensitive lipase in 3T3-L1 adipocytes. Journal of Biochemistry 107, 12.CrossRefGoogle ScholarPubMed
Sztalryd, C., Komaromy, M. & Kraemer, F. (1995). Overexpression of hormone-sensitive lipase prevents triglyceride accumulation in adipocytes. Journal of Clinical Investigation 95, 26522661.CrossRefGoogle ScholarPubMed
Sztalryd, C. & Kraemer, F. B. (1994). Differences in hormone-sensitive lipase expression in white adipose tissue from various anatomic locations of the rat. Metabolism 43, 241247.CrossRefGoogle ScholarPubMed
Sztalryd, C. & Kraemer, F. B. (1994). Regulation of hormone-sensitive lipase during fasting. American Journal of Physiology 266, E179E185.Google ScholarPubMed
Tavernier, G., Galitzky, J., Valet, P., Remaury, A., Bouloumié, A., Lafontan, M. & Langin, D. (1995). Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes. American Journal of Physiology 268, E1135E1142.Google ScholarPubMed
Thompson, M. P., Cooper, S. T., Parry, B. R. & Tuckey, J. A. (1993). Increased expression of the mRNA for hormone-sensitive lipase in adipose tissue of cancer patients. Biochimica et Biophysica Acta 1180, 236242.CrossRefGoogle ScholarPubMed
Wang, S., Lapierre, P., Robert, M.-F., Nadeau, J. H. & Mitchell, G. A. (1994). Hormone-sensitive lipase maps to proximal chromosome 7 in mice and is genetically distinct from the Ad and Tub loci. Genomics 24, 416417.CrossRefGoogle ScholarPubMed
Warden, C. H., Davis, R. C., Yoon, M. Y., Hui, D. Y., Svenson, K., Xia, Y. R., Diep, A., He, K. Y. & Lusis, A. J. (1993). Chromosomal localization of lipoiytic enzymes in the mouse: pancreatic lipase, colipase, hormone-sensitive lipase, hepatic lipase, and carboxyl ester lipase. Journal of Lipid Research 34, 14511455.CrossRefGoogle ScholarPubMed
Warden, C. H., Fisler, J. S., Shoemaker, S. M., Wen, P.-Z., Svenson, K. L., Pace, M. J. & Lusis, A. J. (1995). Identification of four chromosomal loci determining obesity in a multifactorial mouse model. Journal of Clinical Investigation 95, 15451552.CrossRefGoogle Scholar
Wesslau, C., Eriksson, J. & Smith, U. (1993). Cellular cyclic AMP levels modulate insulin sensitivity and responsiveness. Evidence against a significant role of Gi in insulin signal transduction. Biochemical and Biophysical Research Communications 196, 287293.CrossRefGoogle ScholarPubMed
Wilson, B. E., Deeb, S. & Florant, G. L. (1992). Seasonal changes in hormone-sensitive and lipoprotein lipase mRNA concentrations in marmot white adipose tissue. American Journal of Physiology 262, R177R181.Google ScholarPubMed
Wise, L. & Jungas, R. (1978). Evidence for a dual mechanism of lipolysis activation by epinephnr-in rat adipose tissue. Journal of Biological Chemistry 253, 26242627.CrossRefGoogle ScholarPubMed
Wood, S. L., Emmison, N., Borthwick, A. C. & Yeaman, S. J. (1993). The protein phosphatases responsible for dephosphorylation of hormone-sensitive Iipase in isolated rat adipocytes. Biochemical Journal 295, 531535.CrossRefGoogle ScholarPubMed