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Metabolic fuel selection: general integration at the whole-body level

Published online by Cambridge University Press:  28 February 2007

Philip J. Randle
Philip J. Randle
Affiliation:
Nuffield Department of Clinical Biochemistry, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE
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Abstract

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Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 54 , Issue 1 , March 1995 , pp. 317 - 327
Copyright
Copyright © The Nutrition Society 1995

References

Ashcroft, F. M. & Ashcroft, S. J. H. (editors) (1992). Mechanism of insulin secretion. In Insulin, pp. 97–150. Oxford: Oxford University Press.Google Scholar
Brown, G. C. (1992). Control of respiration and ATP synthesis in mammalian mitochondria and cells. Biochemical Journal 284, 1–13.CrossRefGoogle ScholarPubMed
Brownlee, M. (1994). Glycation and diabetic complications. Diabetes 43, 836–841.CrossRefGoogle ScholarPubMed
Brownsey, R. W. & Denton, R. M. (1987). Acetyl CoA carboxylase. In The Enzymes, vol. 18, pp. 123–146 [Boyer, P. D. and Krebs, E. G., editors]. London: Academic Press.Google Scholar
Cahill, G. F. & Owen, O. E. (1968). Some observations on carbohydrate metabolism in man. In Carbohydrate Metabolism and its Disorders, pp. 497–523 [Dicken, F., Randle, P. J. and Whelan, W. J., editors]. London and New York: Academic Press.Google Scholar
Diabetes Control and Complications Trial (1993). The diabetes control and complications trial. New England Journal of Medicine 329, 683–689.Google Scholar
Granner, D. & Pilkis, S. (1990). The genes of hepatic glucose metabolism. Journal of Biological Chemistry 265, 10173–10176.CrossRefGoogle ScholarPubMed
Grill, V. & Zhou, Y. P. (1994). Fatty acids and ketones inhibit β-cell function in human islets of Langerhans. Diabetologia 37, Suppl. 1, A11.Google Scholar
Groop, L. C., Bonadonna, R. C., Delprato, S., Ratheiser, K., Zyck, K., Ferrannini, E. & DeFronzo, R. A. (1989). Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus – evidence for multiple sites of insulin resistance. Journal of Clinical Investigation 84, 205–213.CrossRefGoogle ScholarPubMed
Holness, M. J., Li, Y.-L. & Sugden, M. J. (1989). Time courses of the responses of pyruvate dehydrogenase activities to short term starvation in diaphragm and selected skeletal muscles of the rat. Biochemical Journal 265, 771–776.CrossRefGoogle Scholar
Holness, M. J. & Sugden, M. C. (1990). Glucose utilization in heart, diaphragm and skeletal muscle during the fed to starved transition. Biochemical Journal 270, 245–249.CrossRefGoogle ScholarPubMed
McCormack, J. G., Halestrap, A. P. & Denton, R. M. (1990). Role of calcium ions in regulation of mammalian intramitochondrial metabolism. Physiological Reviews 70, 391–425.CrossRefGoogle ScholarPubMed
Priestman, D. A., Mistry, S. C., Halsall, A. & Randle, P. J. (1994). Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase. Biochemical Journal 300, 659–664.CrossRefGoogle ScholarPubMed
Randle, P. J. (1986). Fuel selection in animals. Nineteenth Ciba medal lecture. Biochemical Society Transactions 14, 799–806.CrossRefGoogle Scholar
Randle, P. J. (1993). Glucokinase and candidate genes for Type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36, 269–275.CrossRefGoogle ScholarPubMed
Randle, P. J., Priestman, D. A., Mistry, S. C. & Halsall, A. (1994 a). Glucose fatty acid interactions and the regulation of glucose disposal. Journal of Cellular Biochemistry 555, 1–11.CrossRefGoogle Scholar
Randle, P. J., Priestman, D. A., Mistry, S. C. & Halsall, A. (1994 b). Mechanisms modifying glucose oxidation in diabetes. Diabetologia 37, Suppl. 2, S155–S161.CrossRefGoogle ScholarPubMed
Reed, L. J. & Yeaman, S. J. (1987). Pyruvate dehydrogenase. In The Enzymes, vol. 18, pp. 77–95 [Boyer, P. D. and Krebs, E. G., editors]. London: Academic Press.Google Scholar
Sako, Y. & Grill, V. E. (1990). A 48 h lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and β cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 127, 1580–1589.CrossRefGoogle Scholar
Sekine, N., Cirulli, V., Regazzi, R., Brown, L. J., Gine, E., Tamarit-Rodriguez, J., Girotti, M., Marie, S., Macdonald, M. J. & Wollheim, C. B. (1994). Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta cells. Potential role in glucose sensing. Journal of Biological Chemistry 269, 4895–4902.CrossRefGoogle Scholar
Strålfors, P., Olsson, H. & Belfrage, P. (1987). Hormone-sensitive lipase. In The Enzymes, vol. 18, pp. 147–177 [Boyer, P. D. and Krebs, E. G., editors]. London: Academic Press.Google Scholar
Thiébaud, D., Jacot, E., DeFronzo, R. A., Maeder, E., Jéquier, E. & Felber, J.-P. (1982). The effect of graded doses of insulin on total glucose uptake, glucose oxidation and glucose storage in man. Diabetes 31, 957–963.CrossRefGoogle ScholarPubMed
Zhou, Y. P. & Grill, V. (1994 a). Evidence that fatty acids inhibit β-cell function through activation of PDH kinase. Diabetologia 37, Suppl. 1, A11.Google Scholar
Zhou, Y. P. & Grill, V. (1994 b). Long term exposure of rat pancreatic islets inhibits glucose-induced secretion and biosynthesis through a glucose fatty acid cycle. Journal of Clinical Investigation 93, 870–876.CrossRefGoogle ScholarPubMed