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Probiotics and allergy

Published online by Cambridge University Press:  07 March 2007

Elizabeth Furrie
Elizabeth Furrie
Affiliation:
Department of Immunology, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
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Abstract

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Allergy is caused by an immune reaction that is out of all proportion to the antigenic stimuli. Classical allergy is a type I hypersensitivity reaction mediated by the interaction of mast cells (and eosinophils) coated with allergen-specific IgE and a cross-linking allergen. The physiological outcome is inflammation commonly displayed by urticaria, rhinitis, vomiting and diarrhoea, depending on the route of allergen entry. In extreme reactions anaphylactic shock can result that may lead to death. Chronic allergic responses most commonly present themselves as asthma and eczema. All these symptoms are the consequence of an imbalanced immune system making an unsuitable response to an environmental or food antigen. On bacterial colonisation of the colon after birth the appropriate microbiological stimuli is essential to redress the balance of the skewed T-helper 2 immune response present in the newborn. This normal interaction between baby and microbes is thought to be compromised in the Western world, with a reduction in bifidobacteria and an increase in clostridial species, particularly in bottle-fed infants. The use of probiotic therapy to prevent allergic disease has been demonstrated in two studies using a probiotic Lactobacillus rhamnosus GG in neonates. A long-term reduction in allergy has been shown in the test group, with lactobacillus reducing the incidence of atopic eczema. Management of allergy through probiotics has also been demonstrated in infants, using lactobacilli to control atopic eczema and cow's milk allergy. Unfortunately, these positive results have not been repeated in studies with older children and young adults.

Keywords

ProbioticsManagement of allergyPrevention of allergyInfants
Type
Symposium on ‘Reacting to allergy’
Information
Proceedings of the Nutrition Society , Volume 64 , Issue 4 , November 2005 , pp. 465 - 469
Copyright
Copyright © The Nutrition Society 2005

References

Baumgart, DC & Dignass, AU (2002) Intestinal barrier function. Current Opinion in Clinical Nutrition and Metabolic Care 5, 685–694 Google Scholar
Bjorksten, B, Naaber, P, Sepp, E & Mikelsaar, M (1999) The intestinal microflora in allergic Estonian and Swedish 2-year old children. Clinical and Experimental Allergy 29, 342–346 Google Scholar
Bjorksten, B, Sepp, E, Julge, K, Voor, T & Mikelsaar, M (2001) Allergy development and the intestinal microflora during the first year of life. Journal of Allergy and Clinical Immunology 108, 516–520 CrossRefGoogle ScholarPubMed
Bottcher, MF, Nordin, EK, Sandin, A, Midtvedt, T & Bjorksten, B (2000) Microflora-associated characteristics in faeces from allergic and non-allergic infants. Clinical and Experimental Allergy 30, 1590–1596 CrossRefGoogle Scholar
Buning, J, Schmitz, M, Repenning, B, Ludwig, D, Schmidt, MA, Strobel, S, Zimmer, K-Ph (2005) Interferon γ mediates antigen trafficking to MHC class II positive late endosomes of enterocytes. European Journal of Immunology 35, 831–842 CrossRefGoogle ScholarPubMed
Chaouat, G, Ledee-Bataille, N, Dubanchet, S, Zourbas, S, Sandra, O & Martal, J (2004) Reproductive immunology 2003: reassessing the Th1/Th2 paradigm. Immunology Letters 92, 207–214 Google Scholar
Christensen, HR, Frokiaer, H & Pestka, JJ (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. Journal of Immunology 168, 171–178 CrossRefGoogle ScholarPubMed
Forchielli, ML & Walker, WA (2005) The role of gut-associated lymphoid tissues and mucosal defence. British Journal of Nutrition 93, Suppl. 1. S41–S48.CrossRefGoogle ScholarPubMed
Furrie, E, Smith, RE, Turner, MW, Strobel, S & Mowat, AM (2002) Induction of local innate immune responses and modulation of antigen uptake as mechanisms underlying the mucosal adjuvant properties of immune stimulating complexes (ISCOMS). Vaccine 20, 2254–2262 Google Scholar
Furrie, E, Turner, MW & Strobel, S (1994) Failure of SCID mice to generate an oral tolerogen after a feed of ovalbumin: a role for a functioning gut-associated lymphoid system. Immunology 83, 562–567 Google ScholarPubMed
Hart, AL, Lammers, K, Britishigidi, P, Vitali, B, Rizzello, F, Gionchetti, P, Campieri, M, Kamm, MA, Knight, SC & Stagg, AJ (2004) Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53, 1602–1609 CrossRefGoogle ScholarPubMed
Helin, T, Hahtela, S & Haahtela, T (2002) No effect of oral treatment with an intestinal bacterial strain Lactobacillus rhamnosus (ACTT 53103), on birch pollen allergy: a placebo controlled double blind study. Allergy 57, 243–246 Google Scholar
Hopkins, MJ & Macfarlane, GT (2002) Changes in predominant bacterial populations in human faeces with age and with Clostridium difficile infection. Journal of Medical Microbiology 51, 448–454 CrossRefGoogle ScholarPubMed
Hopkins, MJ, Sharp, R & Macfarlane, GT (2002) Variation in human intestinal microbiota with age. Digestive and Liver Disease 34, Suppl. 2. S12–S18.CrossRefGoogle ScholarPubMed
Ibnou-Zekri, N, Blum, S, Schiffrin, EJ, von der, Weid T (2003) Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro. Infection and Immunity 71, 428–436 CrossRefGoogle ScholarPubMed
Kalliomaki, M, Kirjavainen, P, Eerola, E, Kero, P, Salminen, S & Isolauri, E (2001a) Distinct patterns of neonatal gut microflora in infants whom atopy was and was not developing. Journal of Allergy and Clinical Immunology 107, 129–134 CrossRefGoogle Scholar
Kalliomaki, M, Salminen, S, Arvilommi, H, Kero, P, Koskinen, P & Isolauri, E (2001b) Probiotics in primary prevention of atopic disease: a randomised placebo controlled trial. Lancet 357, 1076–1079 Google Scholar
Kalliomaki, M, Salminen, S, Poussa, T, Arvilommi, H & Isolauri, E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361, 1869–1871 CrossRefGoogle ScholarPubMed
Kirjavainen, PV, Apostolou, E, Arvola, T, Salminen, SJ, Gibson, GR & Isolauri, E (2001) Charaterizing the composition of intestinal microflora as a prospective treatment target in infant allergic disease. FEMS Immunology and Medical Microbiology 32, 1–7 CrossRefGoogle Scholar
Kotowicz, K & Callard, RE (1993) Human immunoglobulin class and IgG subclass regulation: dual action of interleukin-4. European Journal of Immunology 23, 2250–2256 CrossRefGoogle ScholarPubMed
Lampinen, M, Carlson, M, Hakansson, LD & Venge, P (2004) Cytokine-regulated accumulation of eosinophils in inflammatory disease. Allergy 59, 793–805 CrossRefGoogle ScholarPubMed
McCurdy, JD, Olynych, TJ, Maher, LH & Marshall, JS (2003) Distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells. Journal of Immunology 170, 1625–1629 CrossRefGoogle ScholarPubMed
Macfarlane, S, Furrie, E, Cummings, JH & Macfarlane, GT (2004) Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis. Clinical Infectious Diseases 38, 1690–1699 Google Scholar
Majamaa, H & Isolaurie, E (1997) Probiotics: a novel approach in the management of food allergy. Journal of Allergy and Clinical Immunology 99, 179–185 CrossRefGoogle ScholarPubMed
Metchnikoff, E (1910) The Prolongation of Life, pp. 109–116, London, UK: GP Putnam.Google Scholar
Mowat, AM, Parker, LA, Beacock-Sharp, H, Millington, OR & Chirdo, F (2004) Oral tolerance: overview and historical perspectives. Annals of the New York Academy of Sciences 1029, 1–8 CrossRefGoogle ScholarPubMed
O'May, GA & Macfarlane, GT (2005) Probiotic efficacy: are the claims justified? Probiotic Dairy Products, pp. 138–166. [Tamine, AY, editor]. London: Blackwell Publishing.Google Scholar
Pelto, L, Isolaurie, E, Lilius, EM, Nuutila, J & Salminen, S (1998) Probiotic bacteria down regulate the milk induced inflammatory response in milk hypertensive subjects but have an immunostimulatory effect in healthy subjects. Clinical and Experimental Allergy 28, 1474–1479 Google Scholar
Pessi, T, Sutas, Y, Hurme, M & Isolauri, E (2000) Interleukin 10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clinical and Experimental Allergy 30, 1804–1808 Google Scholar
Pohjavuori, E, Viljanen, M, Korpela, R, Kuitunen, M, Tiittanen, M, Vaarala, O & Savilahti, E (2004) Lactobacillus G. effect in increasing IFNγ production in infants with cow's milk allergy. Journal of Allergy and Clinical Immunology 114, 131–136 CrossRefGoogle Scholar
Qin, HL, Shen, TY, Gao, ZG, Fan, XB, Hang, XM, Jiang, YQ & Zhang, HZ (2005) Effect of lactobacillus on the gut microflora and barrier function of the rats with abdominal infection. World Journal of Gastroenterology 11, 2591–2596 CrossRefGoogle ScholarPubMed
Rautava, S, Kalliomaki, M & Isolauri, E (2002) Probiotics during pregnancy and breast-feeding might confer immunomodulatory protection against atopic disease in the infant. Journal of Allergy and Clinical Immunology 109, 119–121 Google Scholar
Rosenfeldt, V, Benfeldt, E, Neilsen, DS, Michaelsen, KF, Jeppesen, DL, Valerius, NH & Paerregaard, A (2003) Effect of probiotic Lactobacillus strains in children with atopic dermatitis. Journal of Allergy and Clinical Immunology 111, 389–395 Google Scholar
Rosenfeldt, V, Benfeldt, E, Valerius, NH, Paerregaard, A & Michaelsen, KF (2004) Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. Journal of Pediatrics 145, 612–616 CrossRefGoogle ScholarPubMed
Sepp, E, Julge, K, Vasar, M, Naaber, P, Bjorksten, B & Mikelsaar, M (1997) Intestinal microflora of Estonian and Swedish infants. Acta Paediatrica 86, 956–961 CrossRefGoogle ScholarPubMed
Wang, MF, Lin, HC, Wang, YY & Hsu, CH (2004) Treatment of perennial allergic rhinitis with lactic acid bacteria. Pediatric Allergy and Immunology 13, 152–158 Google Scholar
Watanabe, S, Narisawa, Y & Arase, S (2003) Differences in fecal microflora between patients with atopic dermatitis and healthy control subjects. Journal of Allergy and Clinical Immunology 111, 587–591 CrossRefGoogle ScholarPubMed