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Zinc and the immune system

Published online by Cambridge University Press:  28 February 2007

Lothar Rink
Lothar Rink*
Affiliation:
Institute of Immunology and Transfusion Medicine, University of Lübeck School of Medicine, Ratzeburger Allee 160, D-23538 Lübeck, Germany
*
Corresponding Author: Dr Lothar Rink, fax +49 451 500 3069, email rink@immu.mu-luebeck.de
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Abstract

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Zn is an essential trace element for all organisms. In human subjects body growth and development is strictly dependent on Zn. The nervous, reproductive and immune systems are particularly influenced by Zn deficiency, as well as by increased levels of Zn. The relationship between Zn and the immune system is complex, since there are four different types of influence associated with Zn. (1) The dietary intake and the resorption of Zn depends on the composition of the diet and also on age and disease status. (2) Zn is a cofactor in more than 300 enzymes influencing various organ functions having a secondary effect on the immune system. (3) Direct effects of Zn on the production, maturation and function of leucocytes. (4) Zn influences the function of immunostimulants used in the experimental systems. Here we summarize all four types of influence on the immune function. Nutritional aspects of Zn, the physiology of Zn, the influence of Zn on enzymes and cellular functions, direct effects of Zn on leucocytes at the cellular and molecular level, Zn-altered function of immunostimulants and the therapeutic use of Zn will be discussed in detail.

Keywords

ZincImmune system

Information

Type
Meeting Report
Information
Proceedings of the Nutrition Society , Volume 59 , Issue 4 , November 2000 , pp. 541 - 552
Copyright
Copyright © The Nutrition Society 2000

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