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Oestrogen-receptors: an overview of recent advances in their structure and function

Published online by Cambridge University Press:  05 December 2011

R. J. B. King
R. J. B. King
Affiliation:
Hormone Biochemistry Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX, U.K.
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Synopsis

Recent advances in our understanding of the receptor components involved in the initial events of oestradiol action are reviewed with an emphasis on aspects of clinical relevance. Two main features of the models have evolved: (1) the domain structure of the ligand-binding unit, with distinct parts of the molecule being concerned with oestrogen-binding and interaction with DNA, and other parts of the molecule having important regulatory functions; (2) the regulatory regions (oestrogen-response elements) of oestrogen-sensitive genes which specifically interact with the receptor protein.

The homologies between different proteins capable of binding ligands as diverse as oestradiol, retinoic acid and thyroid hormone point to possible interactions between such ligands. Oestrogen-response elements can recognise oestradiol receptor proteins complexed with either agonists or antagonists. Interactions with DNA may play an important rôle in determining gene expression additional to those seen at the receptor level.

Type
Research Article
Information
Proceedings of the Royal Society of Edinburgh, Section B: Biological Sciences , Volume 95: Oestrogen and the Human Breast , 1989 , pp. 133 - 144
Copyright
Copyright © Royal Society of Edinburgh 1989

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