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p53 Family members p63 and p73 are SAM domain-containing proteins

Published online by Cambridge University Press:  01 August 1999

CHRISTOPHER D. THANOS  and
JAMES U. BOWIE
CHRISTOPHER D. THANOS
Affiliation:
UCLA-DOE Laboratory of Structural Biology and Molecular Medicine and Department of Chemistry and Biochemistry, University of California–Los Angeles, Los Angeles, California 90095
JAMES U. BOWIE
Affiliation:
UCLA-DOE Laboratory of Structural Biology and Molecular Medicine and Department of Chemistry and Biochemistry, University of California–Los Angeles, Los Angeles, California 90095
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Abstract

Homologs of the tumor suppressor p53, called p63 and p73, have been identified. The p63 and p73 family members possess a domain structure similar to p53, but contain variable C-terminal extensions. We find that some of the C-terminal extensions contain Sterile Alpha Motif (SAM) domains. SAM domains are protein modules that are involved in protein–protein interactions. Consistent with this role, the C-terminal SAM domains of the p63 and p73 may regulate function by recruiting other protein effectors.

Keywords

Sterile Alpha Motiftumor suppressor
Type
FOR THE RECORD
Information
Protein Science , Volume 8 , Issue 8 , August 1999 , pp. 1708 - 1710
Copyright
© 1999 The Protein Society

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