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Modèles animaux sensibles aux antidépresseurs: implication des systèmes sérotoninergiques et noradrénergiques centraux

Published online by Cambridge University Press:  28 April 2020

P Martin ,
MH Thiébot  and
AJ Puech
P Martin
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
MH Thiébot
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
AJ Puech
Affiliation:
Département de pharmacologie, faculté de médecine Pitié-Salpêtrière, 91, boulevard de l'Hôpital, 75634 Paris Cedex 13, France
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Résumé

Tenter de vouloir modéliser chez l’animal une pathologie psychiatrique peut sembler tout à fait illusoire. Il est en revanche plus aisé d’analyser «les grandes fonctions» qui modulent le comportement, ainsi que les systèmes neurobiologiques impliqués dans leur régulation. À travers deux tests comportementaux sensibles aux antidépresseurs: le modèle de «Learned Helplessness» ou «renoncement appris» et le test du labyrinthe en T, mesurant une capacité à attendre; nous avons voulu montrer que les effets de substances antidépressives pouvaient agir sur deux dimensions différentes et de quelle(s) manière(s) pouvaient être impliqués les systèmes sérotoninergiques.

Summary

Summary

Behavioral models of psychiatric disorders do not simulate or reproduce human mental pathology in animals. However, it is possible to evaluate the behavioral and biochemical changes in experimental situations and to propose hypotheses concerning the functions of the CNS. Using 2 tests sensitive to antidepressant drugs: the learned helplessness paradigm and a test for waiting capacity in a T-maze, we investigated the involvement of serotoninergic or noradrenergic processes through 2 dimensions: the reversal of escape deficit and the tolerance to delay of reward.

Keywords

systèmes sérotoninergiquessystèmes noradrénergiquesantidépresseurslearned helplessness paradigmcapacité à attendreimpulsivitéserotoninergic, noradrenergic Systemsantidepressant drugslearned helplessness paradigmwaiting capacityimpulsivity
Type
Article Original
Information
Psychiatry and Psychobiology , Volume 5 , Issue 3 , 1990 , pp. 209 - 217
Copyright
Copyright © European Psychiatric Association

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References

Références

Bizot, JC, Thiébot, MH, Le Bihan, C, Soubrié, P, Simon, P (1988) Effects of Imipramine-Like Drugs and Serotonin Uptake Blockers on Delay of Reward in Rats. Possible Implication in the Behavioral Mechanism of Action of Antidepressants. J Pharmacol Exp Ther 246, 1144–1151Google ScholarPubMed
Dorworth, T, Overmier, JB (1977) On Learned Helplessness: the Therapeutic Effects of Electroconvulsive Shocks. Physiol Psychol 5, 355–358CrossRefGoogle Scholar
Herrnstein, RJ (1981) Self Control as Response Strength. In: Quantification of Steady State Operant Behavior (Bradshaw, CM, Szabadl, E, Lowe, CF, eds), Elsevier, Amsterdam, 3-20Google Scholar
Kraemer, GW, Ebert, MH, Lake, CR, McKinney, WT (1984) Cerebrospinal Fluid Measures of Neurotransmitter Changes Associated with Pharmacological Alteration of the Despair Response to Social Séparation in Rhesus Monkeys. Psychiatry Res 11, 303–315CrossRefGoogle ScholarPubMed
Kametani, H, Nomura, S, Shimizu, J (1983) The Reversal Effect of Antidepressant on Escape Déficit Induced by Inescapable Shock in Rats. Psychopharmacology 80, 206–208CrossRefGoogle ScholarPubMed
Maier, SF, Seligman, MEP (1976) Learned Helplessness: Theory and Evidence. J Exp Psychol Gen 105, 3–46CrossRefGoogle Scholar
Martin, P, Brochet, D, Soubrié, P, Simon, P (1985) Triiodothyronine-Induced Reversal of Learned Helplessness in Rats. Biol Psychiatry 20, 1023–1025CrossRefGoogle ScholarPubMed
Martin, P, Soubrié, P, Simon, P (1986a) Shuttle-box Deficits Induced by Inescapable Shocks in Rats: Reversal by the Beta-Adrenoceptor Stimulants Clenbuterol and Salbutamol. Phannacol Biochem Behav 24, 177–181CrossRefGoogle Scholar
Martin, P, Soubrié, P, Simon, P (1986b) Noradrenergic and Opioid Mediation of Tricyclic-lnduced Reversal of Escape Deficits caused by Inescapable Shock Pretreatment in Rats. Psychopharmacology 90, 90–94CrossRefGoogle Scholar
Martin, P, Soubrié, P, Simon, P (1987a) The Effect of Monoamine Oxidase Inhibitors Compared with Classical Tricyclic Antidepressants on Learned Helplessness Paradigm. Prog Neuropsychopharmacol Biol Psychiatry 11, 1–7CrossRefGoogle Scholar
Martin, P, Massol, J, Belon, JP, Gaudel, G, Soubrié, P (1987b) Thyroid Function and Reversal by Antidepressant Drugs of Depressive-Like Behavior (escape deficits) in Rats. Neuropsychobiology 18, 21–26CrossRefGoogle Scholar
Martin, P, Laporte, AM, Soubrié, P, El, Mestikawy S, Hanton, M (1987c) Reversal of Helpless Behavior in Rats by Serotonin uptake Inhibitors. International Conférence Behavioural Pharmacology of 5-HT, Amsterdam, November 24-27Google Scholar
Martin, P, Beninger, R, Massol, J, Laporte, AM, El, Mestikawy S, Soubrié, P, Hamon, M, Puech, AJ (1988) Antidepressant-Like Action of 8-OH-DPAT, a 5-HT1A agonist, in the Learned Helplessness Paradigm: pre- or post-synaptic mechanism? XVIth Collegium Internationale Neuro-Psychopharmacologicum, Congress Munich, August 15-19, Psychophannacology 96, 262Google Scholar
Martin, P, Soubrié, P, Puech, AJ (1990a) New Approach of Learned Helplessness Paradigm in Rats: Effects of Antidepressant Drugs. Psychiatr Psychobiol (soumis)Google Scholar
Martin, P, Soubrié, P, Puech, AJ (1990b) Reversal of Helpless Behavior by Serotonin uptake Inhibitors in Rats. Psychopharmacology (in press)CrossRefGoogle Scholar
Massol, J, Martin, P, Soubrié, P, Simon, P (1987) Triiodothyroacetic Acid Induced Reversal of Learned Helplessness in Rats. Eur J Phannacol 134, 345–348CrossRefGoogle ScholarPubMed
McElroy, JF, Dupont, AF, Feldman, RS (1982) The Effects of Fenfluramine and Fluoxetine on the Acquisition of a Conditioned Avoidance Response in Rats. Psychopharmacology 77, 356–359CrossRefGoogle ScholarPubMed
McKinney, WT (1977) Biobehavioral Models of Depression in Monkeys. In: Animal Models in Psychiatry and Neurology (Usdin, E, Hanin, I, eds), Pergamon Press, Oxford, 117-126Google Scholar
Miller, WR, Rosellini, RA, Seligman, MEP (1977) Learned Helplessness and Depression. In: Psychopathology: Experimental Models (Maser, J, Seligman, MEP, eds) Freeman, San Francisco & Co, 104-130Google Scholar
Petty, F, Sherman, AD (1980) Regional Aspects of the Prevention of Learned Helplessness by Desiprarnine. Life Sci 26, 1447–1452CrossRefGoogle Scholar
Seligman, MEP, Maier, SF (1967) Failure to Escape Traumatic Shock. J Exp Psychol 74, 1–9CrossRefGoogle ScholarPubMed
Sherman, AD, Sacquitne, JL, Petty, F (1982) Specificity of the Learned Helplessness Model of Depression. Phannacol Biochem Behav 1, 449–454CrossRefGoogle Scholar
Soubrié, P, Martin, P, El, Mestikawy S, Thiébot, MH, Simon, P, Hamon, M (1986) The Lesion of Serotonergic Neurons does not prevent Antidepressant- Induced Reversal of Escape Failures Produced by Inescapable Shocks in Rats. Phannacol Biochem Behav 25, 1–6CrossRefGoogle Scholar
Soubrié, P, Martin, P, El, Mestikawy S, Hamon, M (1987) Delayed Behavioral Response to Antidepressant Drugs Following Selective Damage to the Hippocampal Noradrenergic Innvervation in Rats. Brain Res 437, 323–331CrossRefGoogle Scholar
Thiébot, MH, Le Bilian, C, Soubrié, P, Simon, P (1985) Benzodiazepines Reduce Tolerance to Reward delay in Rats. Psychopharmacology 86, 147–152CrossRefGoogle ScholarPubMed
Weiss, JM, Glazer, HI (1975) Effects of Acute Exposure to Stressors on Subsequent Avoidance-Escape Behavior. Psychosom Med 37, 499–521CrossRefGoogle ScholarPubMed
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