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Adjacent genetic markers on chromosome 11p15.5 at or near the tyrosine hydroxylase locus that show population linkage disequilibrium with each other do not show allelic association with bipolar affective disorder

Published online by Cambridge University Press:  01 November 1999

A. McQUILLIN ,
J. LAWRENCE ,
D. CURTIS ,
G. KALSI ,
C. SMYTH ,
S. HANNESDOTTIR  and
H. GURLING
A. McQUILLIN
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
J. LAWRENCE
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
D. CURTIS
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
G. KALSI
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
C. SMYTH
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
S. HANNESDOTTIR
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
H. GURLING
Affiliation:
Molecular Psychiatry Laboratory, Department of Psychiatry, Royal Free and University College London Medical School and Department of Psychological Medicine, St Bartholomew's and Royal London School of Medicine and Dentistry, London
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Abstract

Background. Linkage and association studies have suggested genetic susceptibility to bipolar affective disorder in a region of chromosome 11 around the tyrosine hydroxylase locus. We attempted to test the hypothesis that there was allelic association between polymorphisms around the tyrosine hydroxylase locus and bipolar affective disorder.

Methods. A case–control association study was employed using four polymorphic markers, which span a region of approximately 2 cM across the tyrosine hydroxylase locus.

Results. No evidence for allelic association between bipolar affective disorder and any of these markers was found. However, linkage disequilibrium between the markers was detected.

Conclusions. This finding diminishes the probability that genes in this region influence susceptibility to bipolar affective disorder, at least in our sample.

Type
BRIEF COMMUNICATION
Information
Psychological Medicine , Volume 29 , Issue 6 , November 1999 , pp. 1449 - 1454
Copyright
© 1999 Cambridge University Press

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