Hostname: page-component-7479d7b7d-jwnkl Total loading time: 0 Render date: 2024-07-13T07:26:18.609Z Has data issue: false hasContentIssue false
  • English
  • Français

The cerebral cortical appearance in depressed subjects

Published online by Cambridge University Press:  09 July 2009

R. J. Dolan ,
S. P. Calloway ,
P. F. Thacker  and
A. H. Mann
R. J. Dolan*
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
S. P. Calloway
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
P. F. Thacker
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
A. H. Mann
Affiliation:
Academic Department of Psychiatry, Royal Free Hospital, London
*
1Address for correspondence: Dr R. J. Dolan, Department of Psychological Medicine, The National Hospital for Nervous Diseases, Queen Square, London WC1N 3BG.
Get access Rights & Permissions [Opens in a new window]

Synopsis

This paper describes a comparison of the cerebral cortical appearance of 101 patients with a history of clinical depression and 52 control subjects. An age-related increase in sulcal widening was evident in both groups. However, after controlling for age, the patients were found to differ from control subjects in two respects: they had a greater amount of sulcal widening, most noticeably in the frontal and temporal areas; and there was a positive correlation between increasing sulcal widening and increasing lateral ventricular size not found in the control subjects. Patients with a past history of treatment by electroconvulsive therapy showed more sulcal widening in the parietal and occipital areas than those not so treated.

Type
Research Article
Information
Psychological Medicine , Volume 16 , Issue 4 , November 1986 , pp. 775 - 779
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Andreasen, N. C., Smith, M. R., Jacoby, C. G., Dennert, J. W. & Olsen, S. A. (1982). Ventricular enlargement in schizophrenia: definition and prevalence. American Journal of Psychiatry 139, 292–296.Google ScholarPubMed
Baker, R. S. & Nelder, S. A. (1978). The GLIM System. Release 3: Generalised Linear Interactive Modelling. Royal Statistical Society: London.Google Scholar
Calloway, S. P., Dolan, R. J., Jacoby, R. J. & Levy, R. (1981). ECT and cerebral atrophy. Acta Psychiatrica Scandinavica 64, 442–445.CrossRefGoogle ScholarPubMed
Dolan, R. J., Calloway, S. P. & Mann, A. H. (1985). Cerebral ventricular size in depressed subjects. Psychological Medicine 15, 873–878.CrossRefGoogle ScholarPubMed
Everitt, B. S. & Dunn, G. (1983). Advanced Methods of Data Exploration and Modelling. Heinemann Educational Books: London.Google Scholar
Golden, C. J., Moses, J. A. Jr, Zelazowski, R., Graber, B., Zatz, L. M., Horvath, T. B. & Berger, P. A. (1980). Cerebral ventricular size and neuropsychological impairment in young chronic schizophrenics: measurement by the standardised Luria-Nebraska Neuropsychological Battery. Archives of General Psychiatry 37, 619–623.CrossRefGoogle ScholarPubMed
Hull, H. C. & Nie, H. H. (1981). SPSS Update 7–9: New Procedures and Facilities for Releases 7–9. McGraw-Hill: New York.Google Scholar
Jacoby, R. J. & Levy, R. (1980). Computed tomography in the elderly: 3. Affective disorder. British Journal of Psychiatry 136, 270–275.CrossRefGoogle ScholarPubMed
Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982). Cerebral ventricular enlargement in young manic males: a controlled CT study. Journal of Affective Disorders 4, 15–19.CrossRefGoogle Scholar
Rieder, R., Mann, L. S., Weinberger, D. R., van Kammen, D. P. & Post, R. M. (1983). Computed tomographic scans in patients with schizophrenia, schizo-affective and bipolar affective disorder. Archives of General Psychiatry 40, 735–739.CrossRefGoogle Scholar
Ron, M. A. (1983). The Alcoholic Brain: CT Scan and Psychological Findings. Psychological Medicine. Monograph Supplement 3. Cambridge University Press: Cambridge.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1978). Research diagnostic criteria. Rationale and reliability. Archives of General Psychiatry 35, 773–782.CrossRefGoogle ScholarPubMed
Tanaka, Y., Hazama, H., Fukuhara, T. & Tsutsui, T. (1982). Computerised tomography of the brain in manic-depressive patients – a controlled study. Folia Psychiatrica et Neurologica Japonica 36, 137–144.Google ScholarPubMed
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986). Computerized tomographic scan changes in early schizophrenia – preliminary findings. Psychological Medicine 16, 219–225.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 a). Lateral cerebral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry 36, 735–739.CrossRefGoogle ScholarPubMed
Weinberger, D. R., Torrey, E. F., Neophytides, A. N. & Wyatt, R. J. (1979 b). Structural abnormalities in the cerebral cortex of chronic schizophrenia patients. Archives of General Psychiatry 36, 935–939.CrossRefGoogle Scholar