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Cerebral ventricle dimensions as risk factors for schizophrenia and affective psychosis: an epidemiological approach to analysis

Published online by Cambridge University Press:  09 July 2009

P. B. Jones ,
I. Harvey ,
S. W. Lewis ,
B. K. Toone ,
J. Van Os ,
M. Williams  and
R. M. Murray
P. B. Jones*
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
I. Harvey
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
S. W. Lewis
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
B. K. Toone
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
J. Van Os
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
M. Williams
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
R. M. Murray
Affiliation:
Department of Pyschological Medicine, Institute of Psychiatry and King's College Hospital, London
*
1Address for correspondence: Dr P. B. Jones, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London SE5 8AF
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Synopsis

A case–control study was undertaken of volumetric computerized tomographic scan measures in 216 consecutive admissions for functional psychosis and 67 healthy community controls. Odds ratio analysis demonstrated significant linear trends in the association between increasing lateral and third ventricle volumes, and both RDC schizophrenia (N = 121) and schizoaffective disorder (N = 41); cases were consistently associated with larger volumes than controls. There was an association between larger third, but not lateral, ventricle size in affective psychoses (N = 54). These associations were statistically independent of intracranial volume, sex, social class and ethnicity, factors which were significantly associated with ventricular measures in the controls. There was no evidence of a threshold corresponding to the notion of normal versus enlarged ventricles.

Within the schizophrenia group, there were no large or significant associations between ventricle dimensions and age at onset, duration of illness or pre-morbid social functioning. Neither obstetric complications nor a family history of schizophrenia or other psychiatric illness was associated with large ventricles in these cases.

Type
Original Articles
Information
Psychological Medicine , Volume 24 , Issue 4 , November 1994 , pp. 995 - 1011
Copyright
Copyright © Cambridge University Press 1994

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