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HLA antigens and manic-depressive disorders: further evidence of an association

Published online by Cambridge University Press:  09 July 2009

Robert W. Shapiro ,
Lars P. Ryder ,
Arne Svejgaard  and
Ole J. Rafaelsen
Robert W. Shapiro*
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Lars P. Ryder
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Arne Svejgaard
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
Ole J. Rafaelsen
Affiliation:
Psychochemistry Institute, Department of Psychiatry, and the Tissue-typing Laboratory, Blood-grouping Department, Rigshospitalet, Copenhagen, Denmark
*
1Address for correspondence: Dr Robert W.Shapiro, Massachusett Mental Health Center, Boston Psycho pathic Hospital, 72–76 Fenwood Road, Boston, Mass. 02115, U.S.A.
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Synopsis

One hundred and seven unrelated Danish patients considered to be manic-depressive according to strict diagnostic, symptomatic and course criteria were typed for antigens of the HLA system, the major histocompatibility system in man. Preliminary results from the first 47 patients had previously been reported to suggest a positive association between manic-depressive disorders and HLA-A3, HLA-B7, and HLA-Bw16 and a negative association between such disorders and HLA-B8. Results from the extended series provide confirmatory evidence that there is a positive association between manic-depressive disorders and HLA-Bw16 and also strongly suggest a positive association between HLA-B7 and such disorders. HLA typing may prove to be a useful way of identifying sub-groups of manic-depressive patients for other biological studies. The associations described provide a potential lead for formulating hypotheses about the nature of the biological mechanisms which predispose to manic-depressive disorders.

Type
Research Article
Information
Psychological Medicine , Volume 7 , Issue 3 , August 1977 , pp. 387 - 396
Copyright
Copyright © Cambridge University Press 1977

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