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Local cortical thinning links to resting-state disconnectivity in major depressive disorder

Published online by Cambridge University Press:  01 November 2013

M.-J. van Tol ,
M. Li ,
C. D. Metzger ,
N. Hailla ,
D. I. Horn ,
W. Li ,
H. J. Heinze ,
B. Bogerts ,
J. Steiner  and
H. He
...Show all authors
M.-J. van Tol
Affiliation:
NeuroImaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
M. Li
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China
C. D. Metzger
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
N. Hailla
Affiliation:
Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
D. I. Horn
Affiliation:
Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
W. Li
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China
H. J. Heinze
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany Department of Neurology, Otto von Guericke University, Magdeburg, Germany
B. Bogerts
Affiliation:
Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
J. Steiner
Affiliation:
Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
H. He*
Affiliation:
State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China
M. Walter*
Affiliation:
Leibniz Institute for Neurobiology, Magdeburg, Germany Clinical Affective Neuroimaging Laboratory, Center for Behavioral Brain Sciences, Magdeburg, Germany State Key Laboratory of Management and Control for Complex Systems, Institute of Automation, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany
*
*Address for correspondence: M. Walter, M.D., Ph.D., Department of Psychiatry and Leibniz Institute for Neurobiology, Otto von Guericke University, Brenneckestrasse 6, 39118 Magdeburg, Germany. (Email: martin.walter@med.ovgu.de) [M. Walter] (Email: huiguang.he@ia.ac.cn) [H. He]
*Address for correspondence: M. Walter, M.D., Ph.D., Department of Psychiatry and Leibniz Institute for Neurobiology, Otto von Guericke University, Brenneckestrasse 6, 39118 Magdeburg, Germany. (Email: martin.walter@med.ovgu.de) [M. Walter] (Email: huiguang.he@ia.ac.cn) [H. He]
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Abstract

Background

Local structural and metabolic as well as inter-regional connectivity abnormalities have been implicated in the neuropathology of major depressive disorder (MDD). How local tissue properties affect intrinsic functional connectivity is, however, unclear. Using a cross-sectional, multi-modal imaging approach, we investigated the relationship between local cortical tissue abnormalities and intrinsic resting-state functional connectivity (RSFC) in MDD.

Method

A total of 20 MDD in-patients and 20 healthy controls underwent magnetic resonance imaging at 3 T for structural and functional imaging. Whole-brain cortical thickness was calculated and compared between groups. Regions with reduced cortical thickness defined seeds for subsequent whole-brain RSFC analyses. Contributions of structural tissue abnormalities on inter-regional RSFC were explicitly investigated.

Results

Lower cortical thickness was observed in MDD in the right dorsomedial prefrontal cortex (PFC), superior temporal gyrus/temporal pole, middle-posterior cingulate cortex, and dorsolateral PFC. No differences in local fractional amplitude of low-frequency fluctuations were observed. Lower thickness in patients' dorsomedial PFC further directly and selectively affected its RSFC with the precuneus, which was unaffected by symptom severity. No effects of cortical thickness in other regions showing abnormal thickness were observed to influence functional connectivity.

Conclusions

Abnormal cortical thickness in the dorsomedial PFC in MDD patients was observed to selectively and directly affect its intrinsic connectivity with the precuneus in MDD patients independent of depression severity, thereby marking a potential vulnerability for maladaptive mood regulation. Future studies should include an unmedicated sample and replicate findings using independent component analysis to test for morphometric effects on network integrity.

Keywords

Cortical thicknessfractional amplitude of low-frequency fluctuationsfunctional connectivitymajor depressive disordermultimodal imagingresting-state functional magnetic resonance imaging
Type
Original Articles
Information
Psychological Medicine , Volume 44 , Issue 10 , July 2014 , pp. 2053 - 2065
Copyright
Copyright © Cambridge University Press 2013 

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