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Neurocognitive impairment in deficit and non-deficit schizophrenia: a meta-analysis

Published online by Cambridge University Press:  04 May 2017

E. Bora ,
B. Binnur Akdede  and
K. Alptekin
E. Bora*
Affiliation:
Department of Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia
B. Binnur Akdede
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia
K. Alptekin
Affiliation:
Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Victoria 3053, Australia
*
*Address for correspondence: Dr E. Bora, Department of Psychiatry, Dokuz Eylul University School of Medicine, Izmir, Turkey. (Email: emre.bora@deu.edu.tr, ibora@unimelb.edu.au)
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Abstract

Background

Most studies suggested that patients with deficit schizophrenia have more severe impairment compared with patients with non-deficit schizophrenia. However, it is not clear whether deficit and non-deficit schizophrenia are associated with differential neurocognitive profiles.

Methods

The aim of this meta-analytic review was to compare cognitive performances of deficit and non-deficit patients with each other and with healthy controls. In the current meta-analysis, differences in cognitive abilities between 897 deficit and 1636 non-deficit patients with schizophrenia were examined. Cognitive performances of 899 healthy controls were also compared with 350 patients with deficit and 592 non-deficit schizophrenia.

Results

Both deficit (d = 1.04–1.53) and non-deficit (d = 0.68–1.19) schizophrenia were associated with significant deficits in all cognitive domains. Deficit patients underperformed non-deficit patients in all cognitive domains (d = 0.24–0.84) and individual tasks (d = 0.39–0.93). The relationship between deficit syndrome and impairment in olfaction, social cognition, verbal fluency, and speed-based cognitive tasks were relatively stronger.

Conclusions

Our findings suggest that there is consistent evidence for a significant relationship between deficit syndrome and more severe cognitive impairment in schizophrenia.

Keywords

Cognitiondeficit syndromeschizophrenia
Type
Review Article
Information
Psychological Medicine , Volume 47 , Issue 14 , October 2017 , pp. 2401 - 2413
Copyright
Copyright © Cambridge University Press 2017 

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