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Magnetic seizure therapy in treatment-resistant depression: clinical, neuropsychological and metabolic effects

Published online by Cambridge University Press:  25 November 2014

S. Kayser
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bonn, Germany
B. H. Bewernick
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bonn, Germany
A. Matusch
Affiliation:
Institute of Neurosciences and Medicine (INM-2), Forschungszentrum Jülich, Germany
R. Hurlemann
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bonn, Germany
M. Soehle
Affiliation:
Department of Anaesthesiology and Intensive Care Medicine, University of Bonn, Germany
T. E. Schlaepfer*
Affiliation:
Department of Psychiatry and Psychotherapy, University of Bonn, Germany Departments of Psychiatry and Mental Health, The Johns Hopkins University, Baltimore, MD, USA
*
* Address for correspondence: T. E. Schlaepfer, M.D., Department of Psychiatry and Psychotherapy, University Hospital, Sigmund-Freud-Straße 25, 53105 Bonn, Germany. (Email: schlaepf@jhmi.edu)

Abstract

Background.

Magnetic seizure therapy (MST), despite being in an early phase of clinical research, has been demonstrated to be associated with antidepressant efficacy. However, safety, tolerability and efficacy data in connection with functional brain activity from larger samples are lacking. The aim of this study was to determine clinical and cognitive effects of MST and the influence of MST on regional brain glucose metabolism.

Method.

Twenty-six patients suffering from treatment-resistant depression (TRD) underwent MST. Ten patients underwent a randomized trial and 16 patients an open-label study design. The primary outcome criterion was the severity of depressive symptoms assessed with the Hamilton Depression Rating Scale (HAMD). Depressive symptoms, tolerability and cognitive safety, along with social functioning and quality of life parameters, were assessed using various rating scales. A clinical follow-up visit 6 months following the completion of a course of MST and [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans of 12 patients were analysed.

Results.

A significant response to MST was demonstrated by 69% of the patient sample, with 46% meeting remission criteria. Anxiety ratings were significantly reduced in responders and their quality of life was improved. Half of the responders relapsed within 6 months. No cognitive side-effects were observed. FDG-PET scans showed a metabolic increase in the frontal cortex bilaterally and a decrease in the left striatum.

Conclusions.

Robust antidepressant and anti-anxiety efficacy of MST was demonstrated, and found to be associated with localized metabolic changes in brain areas that are strongly implicated in depression. Thus, MST presents an effective, well-tolerated and safe treatment option for patients unable to respond to other forms of therapy for depression.

Type
Original Articles
Copyright
Copyright © Cambridge University Press 2014 

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References

APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn. American Psychiatric Association: Washington, DC.Google Scholar
APA (2000). Handbook of Psychiatric Measures. American Psychiatric Association: Washington, DC.Google Scholar
APA (2001). The Practice of ECT: Recommendations for Treatment, Training and Privileging. American Psychiatric Association: Washington, DC.Google Scholar
Aschenbrenner, A, Tucha, O, Lange, K (eds) (2000). RWT Regensburger Wortflüssigkeits-Test. Handanweisung. Hogrefe: Göttingen.Google Scholar
Austin, MP, Mitchell, P, Goodwin, GM (2001). Cognitive deficits in depression: possible implications for functional neuropathology. British Journal of Psychiatry 178, 200206.Google Scholar
Awata, S, Konno, M, Kawashima, R, Suzuki, K, Sato, T, Matsuoka, H, Fukuda, H, Sato, M (2002). Changes in regional cerebral blood flow abnormalities in late-life depression following response to electroconvulsive therapy. Psychiatry and Clinical Neurosciences 56, 3140.CrossRefGoogle ScholarPubMed
Azuma, H, Fujita, A, Otsuki, K, Nakano, Y, Kamao, T, Nakamura, C, Fujioi, J, Otake, H, Nishigaki, M, Suzuki, M, Kataoka, M, Matsuzawa, T, Sonoda, M, Nakaaki, S, Murata, Y, Akechi, T, Furukawa, TA (2007 a). Ictal electroencephalographic correlates of posttreatment neuropsychological changes in electroconvulsive therapy: a hypothesis-generation study. Journal of ECT 23, 163168.CrossRefGoogle ScholarPubMed
Azuma, H, Fujita, A, Sato, K, Arahata, K, Otsuki, K, Hori, M, Mochida, Y, Uchida, M, Yamada, T, Akechi, T, Furukawa, TA (2007 b). Postictal suppression correlates with therapeutic efficacy for depression in bilateral sine and pulse wave electroconvulsive therapy. Psychiatry and Clinical Neurosciences 61, 168173.CrossRefGoogle ScholarPubMed
Baddeley, AD (1990). Human Memory: Theory and Practice. Lawrence Erlbaum Associates: London.Google Scholar
Baeumler, G (ed.) (1985). Farbe-Wort-Interferenztest (FWIT) nach J.R. Stroop. Hogrefe: Göttingen.Google Scholar
Bartenstein, P, Asenbaum, S, Catafau, A, Halldin, C, Pilowski, L, Pupi, A, Tatsch, K; European Association of Nuclear Medicine (2002). European Association of Nuclear Medicine procedure guidelines for brain imaging using [(18)F]FDG. European Journal of Nuclear Medicine and Molecular Imaging 29, 4348.Google Scholar
Beck, A (ed.) (1987). Beck Depression Inventory: Manual. Psychological Corporation: San Antonio, TX.Google Scholar
Benedict, RH, Zgaljardic, DJ (1998). Practice effects during repeated administrations of memory tests with and without alternate forms. Journal of Clinical and Experimental Neuropsychology 20, 339352.CrossRefGoogle ScholarPubMed
Bernstein, HJ, Beale, MD, Berns, C, Kellner, CH (1998). Patients attitude about ECT after treatment. Annals of General Psychiatry 28, 524527.Google Scholar
Bernstein, JH, Waber, DP (1996). Developmental Scoring System for the Rey-Osterrieth Complex Figure: Professional Manual. Psychological Assessment Resources: Odessa, FL.Google Scholar
Bertolote, JM, Fleischmann, A, De Leo, D, Wasserman, D (2004). Psychiatric diagnoses and suicide: revisiting the evidence. Crisis 25, 147155.Google Scholar
Brickenkamp, R (ed.) (1962). d2. Aufmerksamkeits-Belastungs-Test. Hogrefe: Göttingen.Google Scholar
Buschke, H (1973). Selective reminding for analysis of memory and learning. Journal of Verbal Learning and Verbal Behavior 12, 543550.CrossRefGoogle Scholar
Cockrell, JR, Folstein, MF (1988). Mini-Mental State Examination (MMSE). Psychopharmacology Bulletin 24, 689692.Google Scholar
Cohen, J (1988). Statistical Power Analysis for the Behavioral Sciences. Lawrence Erlbaum Associates: Hillsdale, NJ.Google Scholar
Des Jarlais, DC, Lyles, C, Crepaz, N (2004). Improving the reporting quality of nonrandomized evaluations of behavioral and public health interventions: the TREND statement. American Journal of Public Health 94, 361366.Google Scholar
Devanand, DP, Fitzsimons, L, Prudic, J, Sackeim, HA (1995). Subjective side effects during electroconvulsive therapy. Convulsive Therapy 11, 232240.Google ScholarPubMed
Dikmen, SS, Heaton, RK, Grant, I, Temkin, NR (1999). Test-retest reliability and practice effects of expanded Halstead-Reitan Neuropsychological Test Battery. Journal of the International Neuropsychological Society 5, 346356.CrossRefGoogle ScholarPubMed
Drevets, WC (2001). Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Current Opinion in Neurobiology 11, 240249.Google Scholar
Fava, GA, Ruini, C, Mangelli, L (2001). Patients with depression can be taught how to improve recovery. British Medical Journal 322, 1428.Google Scholar
Fekadu, A, Wooderson, SC, Markopoulo, K, Donaldson, C, Papadopoulos, A, Cleare, AJ (2009). What happens to patients with treatment-resistant depression? A systematic review of medium to long term outcome studies. Journal of Affective Disorders 116, 411.Google Scholar
Fink, M (2001). Convulsive therapy: a review of the first 55 years. Journal of Affective Disorders 63, 115.Google Scholar
Fitzgerald, PB, Hoy, KE, Herring, SE, Clinton, AM, Downey, G, Daskalakis, ZJ (2013). Pilot study of the clinical and cognitive effects of high-frequency magnetic seizure therapy in major depressive disorder. Depression and Anxiety 30, 129136.Google Scholar
Franke, G (1995). SCL-90-R. The Symptom Checklist of Derogatis Revised. German Version [in German]. Beltz: Göttingen.Google Scholar
Fraser, LM, O'Carroll, RE, Ebmeier, KP (2008). The effect of electroconvulsive therapy on autobiographical memory: a systematic review. Journal of ECT 24, 1017.Google Scholar
Grunhaus, L, Hirschman, S, Dolberg, OT, Schreiber, S, Dannon, PN (2001). Coadministration of melatonin and fluoxetine does not improve the 3-month outcome following ECT. Journal of ECT 17, 124128.CrossRefGoogle Scholar
Guze, BH, Baxter, LR Jr., Schwartz, JM, Szuba, MP, Liston, EH (1991). Electroconvulsive therapy and brain glucose metabolism. Convulsive Therapy 7, 1519.Google Scholar
Haerting, C, Markowitsch, HJ, Neufeld, H, Calabrese, P, Deisinger, K, Kessler, J (eds) (2000). WMS-R. Wechsler Memory Scale – Revised [German adaptation]. Huber: Bern.Google Scholar
Hamilton, M (1967). Development of a rating scale for primary depressive illness. British Journal of Social Psychology 6, 278296.Google ScholarPubMed
Hamilton, M (ed.) (1976). HAMA. Hamilton Anxiety Scale. National Institute of Mental Health: Rockville, MD.Google Scholar
Helmstaedter, C, Lendt, M, Lux, S (eds) (2001). VLMT. Verbaler Lern- und Merkfähigkeitstest. Beltz: Göttingen.Google Scholar
Holm, S (1979). A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics 6, 6570.Google Scholar
Hooper, HE (ed.) (1958). The Hooper Visual Organization Test. Western Psychological Services: Beverly Hills, CA.Google Scholar
Hoy, KE, Thomson, RH, Cherk, M, Yap, KS, Daskalakis, ZJ, Fitzgerald, PB (2013). Effect of magnetic seizure therapy on regional brain glucose metabolism in major depression. Journal of Psychiatric Research 211, 169175.Google Scholar
Husain, MM, Rush, AJ, Fink, M, Knapp, R, Petrides, G, Rummans, T, Biggs, MM, O'Connor, K, Rasmussen, K, Litle, M, Zhao, W, Bernstein, HJ, Smith, G, Mueller, M, McClintock, SM, Bailine, SH, Kellner, CH (2004). Speed of response and remission in major depressive disorder with acute electroconvulsive therapy (ECT): a Consortium for Research in ECT (CORE) report. Journal of Clinical Psychiatry 65, 485491.Google Scholar
Jones, SH, Thornicroft, G, Coffey, M, Dunn, G (1995). A brief mental health outcome scale: reliability and validity of the Global Assessment of Functioning (GAF). British Journal of Psychiatry 166, 654659.Google Scholar
Kayser, S, Bewernick, B, Axmacher, N, Schlaepfer, TE (2009). Magnetic seizure therapy of treatment-resistant depression in a patient with bipolar disorder. Journal of ECT 25, 137140.Google Scholar
Kayser, S, Bewernick, BH, Grubert, C, Hadrysiewicz, BL, Axmacher, N, Schlaepfer, TE (2011). Antidepressant effects, of magnetic seizure therapy and electroconvulsive therapy, in treatment-resistant depression. Journal of Psychiatric Research 45, 569576.Google Scholar
Kimball, JN, Rosenquist, PB, Dunn, A, McCall, V (2009). Prediction of antidepressant response in both 2.25 × threshold RUL and fixed high dose RUL ECT. Journal of Affective Disorders 112, 8591.CrossRefGoogle ScholarPubMed
Kirov, G, Ebmeier, KP, Scott, AI, Atkins, M, Khalid, N, Carrick, L, Stanfield, A, O'Carroll, RE, Husain, MM, Lisanby, SH (2008). Quick recovery of orientation after magnetic seizure therapy for major depressive disorder. British Journal of Psychiatry 193, 152155.CrossRefGoogle ScholarPubMed
Kirwan, CB, Bayley, PJ, Galvan, VV, Squire, LR (2008). Detailed recollection of remote autobiographical memory after damage to the medial temporal lobe. Proceedings of the National Academy of Sciences USA 105, 26762680.Google Scholar
Kosel, M, Frick, C, Lisanby, SH, Fisch, HU, Schlaepfer, TE (2003). Magnetic seizure therapy improves mood in refractory major depression. Neuropsychopharmacology 28, 20452048.Google Scholar
Krystal, AD, Weiner, RD, Coffey, CE, Smith, P, Arias, R, Moffett, E (1992). EEG evidence of more ‘intense’ seizure activity with bilateral ECT. Biological Psychiatry 31, 617621.Google Scholar
Krystal, AD, Weiner, RD, McCall, WV, Shelp, FE, Arias, R, Smith, P (1993). The effects of ECT stimulus dose and electrode placement on the ictal electroencephalogram: an intraindividual crossover study. Biological Psychiatry 34, 759767.Google Scholar
Krystal, AD, West, M, Prado, R, Greenside, H, Zoldi, S, Weiner, RD (2000). EEG effects of ECT: implications for rTMS. Depression and Anxiety 12, 157165.Google Scholar
Laupacis, A, Sackett, DL, Roberts, RS (1988). An assessment of clinically useful measures of the consequences of treatment. New England Journal of Medicine 318, 17281733.Google Scholar
Lehrl, S (2005). MWT-B. Mehrfachwahl-Wortschatz-Intelligenztest. Spitta Verlag: Balingen.Google Scholar
Lisanby, SH, Husain, MM, Rosenquist, PB, Maixner, D, Gutierrez, R, Krystal, A, Gilmer, W, Marangell, LB, Aaronson, S, Daskalakis, ZJ, Canterbury, R, Richelson, E, Sackeim, HA, George, MS (2009). Daily left prefrontal repetitive transcranial magnetic stimulation in the acute treatment of major depression: clinical predictors of outcome in a multisite, randomized controlled clinical trial. Neuropsychopharmacology 34, 522534.Google Scholar
Lisanby, SH, Luber, B, Schlaepfer, TE, Sackeim, HA (2003). Safety and feasibility of magnetic seizure therapy (MST) in major depression: randomized within-subject comparison with electroconvulsive therapy. Neuropsychopharmacology 28, 18521865.Google Scholar
Lisanby, SH, Maddox, JH, Prudic, J, Devanand, DP, Sackeim, HA (2000). The effects of electroconvulsive therapy on memory of autobiographical and public events. Archives of General Psychiatry 57, 581590.Google Scholar
Lisanby, SH, Schlaepfer, TE, Fisch, HU, Sackeim, HA (2001). Magnetic seizure therapy of major depression. Archives of General Psychiatry 58, 303305.Google Scholar
Mayberg, HS (2003). Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. British Medical Bulletin 65, 193207.Google Scholar
McCaffrey, RJ, Duff, K, Westervelt, HJ (2000). Practitioner's Guide to Evaluating Change with Intellectual Assessment Instruments. Kluwer Academic/Plenum Press: New York.Google Scholar
McCall, WV, Robinette, GD, Hardesty, D (1996). Relationship of seizure morphology to the convulsive threshold. Convulsive Therapy 12, 147151.Google Scholar
McNeely, HE, Mayberg, HS, Lozano, AM, Kennedy, SH (2008). Neuropsychological impact of Cg25 deep brain stimulation for treatment-resistant depression: preliminary results over 12 months. Journal of Nervous and Mental Disease 196, 405410.Google Scholar
Mendlowicz, MV, Stein, MB (2000). Quality of life in individuals with anxiety disorders. American Journal of Psychiatry 157, 669682.Google Scholar
Montgomery, EB Jr., Gale, JT (2008). Mechanisms of action of deep brain stimulation (DBS). Neuroscience and Biobehavioral Reviews 32, 388407.CrossRefGoogle ScholarPubMed
Montgomery, SA, Åsberg, M (1979). A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382389.Google Scholar
Nobler, MS, Oquendo, MA, Kegeles, LS, Malone, KM, Campbell, CC, Sackeim, HA, Mann, JJ (2001). Decreased regional brain metabolism after ECT. American Journal of Psychiatry 158, 305308.Google Scholar
Nobler, MS, Sackeim, HA, Solomou, M, Luber, B, Devanand, DP, Prudic, J (1993). EEG manifestations during ECT: effects of electrode placement and stimulus intensity. Biological Psychiatry 34, 321330.Google Scholar
Ottosson, JO, Max Fink, M (eds) (2004). Ethics in Electroconvulsive Therapy. Brunner-Routledge: New York.Google Scholar
Parsons, TD, Tucker, KA, Hall, CD, Robertson, WT, Eron, JJ, Fried, MW, Robertson, KR (2006). Neurocognitive functioning and HAART in HIV and hepatitis C virus co-infection. Acquired Immune Deficiency Syndrome 20, 15911595.Google Scholar
Paykel, ES (2008). Partial remission, residual symptoms, and relapse in depression. Dialogues in Clinical Neuroscience 10, 431437.Google Scholar
Petrides, G, Fink, M, Husain, MM, Knapp, RG, Rush, AJ, Mueller, M, Rummans, TA, O'Connor, KM, Rasmussen, KG Jr., Bernstein, HJ, Biggs, M, Bailine, SH, Kellner, CH (2001). ECT remission rates in psychotic versus nonpsychotic depressed patients: a report from CORE. Journal of ECT 17, 244253.Google Scholar
Prudic, J, Olfson, M, Marcus, SC, Fuller, RB, Sackeim, HA (2004). Effectiveness of electroconvulsive therapy in community settings. Biological Psychiatry 55, 301312.Google Scholar
Regard, M, Strauss, E, Knapp, P (eds) (1982). Der Fuenf-Punkt Test. Department of Neurology, University Hospital: Zurich.Google Scholar
Reitan, RM (ed.) (1959). Trail Making Test. Indiana University Medical Center: Indianapolis, IN.Google ScholarPubMed
Ressler, KJ, Mayberg, HS (2007). Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic. Nature Neuroscience 10, 11161124.Google Scholar
Rey, A (ed.) (1964). L'Examen Clinique en Psychologie. Presse Universitaire de France: Paris.Google Scholar
Rose, D, Fleischmann, P, Wykes, T, Leese, M, Bindman, J (2003). Patients’ perspectives on electroconvulsive therapy: systematic review. British Medical Journal 326, 1363.Google Scholar
Rush, AJ, Trivedi, MH, Wisniewski, SR, Stewart, JW, Nierenberg, AA, Thase, ME, Ritz, L, Biggs, MM, Warden, D, Luther, JF, Shores-Wilson, K, Niederehe, G, Fava, M (2006). Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression. New England Journal of Medicine 354, 12311242.Google Scholar
Rush, AJ, Weissenburger, J, Vinson, DB, Giles, DE (1983). Neuropsychological dysfunctions in unipolar nonpsychotic major depressions. Journal of Affective Disorders 5, 281287.CrossRefGoogle ScholarPubMed
Sackeim, HA (1999). The anticonvulsant hypothesis of the mechanisms of action of ECT: current status. Journal of ECT 15, 526.Google Scholar
Sackeim, HA (2000). Memory and ECT: from polarization to reconciliation. Journal of ECT 16, 8796.CrossRefGoogle ScholarPubMed
Sackeim, HA, George, MS (2008). Brain stimulation – basic, translational and clinical research in neuromodulation: why a new journal? Brain Stimulation 1, 46.Google Scholar
Sackeim, HA, Haskett, RF, Mulsant, BH, Thase, ME, Mann, JJ, Pettinati, HM, Greenberg, RM, Crowe, RR, Cooper, TB, Prudic, J (2001). Continuation pharmacotherapy in the prevention of relapse following electroconvulsive therapy: a randomized controlled trial. Journal of the American Medical Association 285, 12991307.CrossRefGoogle ScholarPubMed
Sackeim, HA, Luber, B, Moeller, JR, Prudic, J, Devanand, DP, Nobler, MS (2000 a). Electrophysiological correlates of the adverse cognitive effects of electroconvulsive therapy. Journal of ECT 16, 110120.Google Scholar
Sackeim, HA, Prudic, J, Devanand, DP, Kiersky, JE, Fitzsimons, L, Moody, BJ, McElhiney, MC, Coleman, EA, Settembrino, JM (1993). Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy. New England Journal of Medicine 328, 839846.Google Scholar
Sackeim, HA, Prudic, J, Devanand, DP, Nobler, MS, Lisanby, SH, Peyser, S, Fitzsimons, L, Moody, BJ, Clark, J (2000 b). A prospective, randomized, double-blind comparison of bilateral and right unilateral electroconvulsive therapy at different stimulus intensities. Archives of General Psychiatry 57, 425434.Google Scholar
Sackeim, HA, Prudic, J, Fuller, R, Keilp, J, Lavori, PW, Olfson, M (2007). The cognitive effects of electroconvulsive therapy in community settings. Neuropsychopharmacology 32, 244254.Google Scholar
Schatzberg, AF, Kraemer, HC (2000). Use of placebo control groups in evaluating efficacy of treatment of unipolar major depression. Biological Psychiatry 47, 736744.Google Scholar
Schlaepfer, TE, Agren, H, Monteleone, P, Gasto, C, Pitchot, W, Rouillon, F, Nutt, DJ, Kasper, S (2012). The hidden third: improving outcome in treatment-resistant depression. Journal of Psychopharmacology 26, 587602.Google Scholar
Semkovska, M, McLoughlin, DM (2010). Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis. Biological Psychiatry 68, 568577.Google Scholar
Silfverskiold, P, Gustafson, L, Risberg, J, Rosen, I (1986). Acute and late effects of electroconvulsive therapy. Clinical outcome, regional cerebral blood flow, and electroencephalogram. Annals of the New York Academy of Sciences 462, 236248.Google Scholar
Spellman, T, McClintock, SM, Terrace, H, Luber, B, Husain, MM, Lisanby, SH (2008). Differential effects of high-dose magnetic seizure therapy and electroconvulsive shock on cognitive function. Biological Psychiatry 63, 11631170.Google Scholar
Takano, H, Motohashi, N, Uema, T, Ogawa, K, Ohnishi, T, Nishikawa, M, Kashima, H, Matsuda, H (2007). Changes in regional cerebral blood flow during acute electroconvulsive therapy in patients with depression: positron emission tomographic study. British Journal of Psychiatry 190, 6368.Google Scholar
Tewes, U (ed.) (1991). HAWIE-R. Hamburg-Wechsler Intelligenztest fuer Erwachsene. Huber: Bern.Google Scholar
Thase, ME, Rush, AJ (1997). When at first you don't succeed: sequential strategies for antidepressant nonresponders. Journal of Clinical Psychiatry 58 (Suppl. 13), 2329.Google Scholar
Trivedi, MH, Rush, AJ, Wisniewski, SR, Nierenberg, AA, Warden, D, Ritz, L, Norquist, G, Howland, RH, Lebowitz, B, McGrath, PJ, Shores-Wilson, K, Biggs, MM, Balasubramani, GK, Fava, M (2006). Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice. American Journal of Psychiatry 163, 2840.Google Scholar
UK ECT Review Group (2003). Efficacy and safety of electroconvulsive therapy in depressive disorders: a systematic review and meta-analysis. Lancet 361, 799808.Google Scholar
Warden, D, Rush, AJ, Wisniewski, SR, Lesser, IM, Kornstein, SG, Balasubramani, GK, Thase, ME, Preskorn, SH, Nierenberg, AA, Young, EA, Shores-Wilson, K, Trivedi, MH (2009). What predicts attrition in second step medication treatments for depression? A STAR*D report. International Journal of Neuropsychopharmacology 12, 459473.Google Scholar
Warden, D, Trivedi, MH, Wisniewski, SR, Davis, L, Nierenberg, AA, Gaynes, BN, Zisook, S, Hollon, SD, Balasubramani, GK, Howland, R, Fava, M, Stewart, JW, Rush, AJ (2007). Predictors of attrition during initial (citalopram) treatment for depression: a STAR*D report. American Journal of Psychiatry 164, 11891197.Google Scholar
Ware, JE Jr., Sherbourne, CD (1992). The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Medical Care 30, 473483.Google Scholar
Weiner, RD, Krystal, AD (eds) (1993 a). EEG Monitoring and Management of Electrically Induced Seizures. American Psychiatric Press: Washington, DC.Google Scholar
Weiner, RD, Krystal, AD (eds) (1993 b). EEG Monitoring of ECT Seizures. American Psychiatric Press: Washington, DC.Google Scholar
White, PF, Amos, Q, Zhang, Y, Stool, L, Husain, MM, Thornton, L, Downing, M, McClintock, S, Lisanby, SH (2006). Anesthetic considerations for magnetic seizure therapy: a novel therapy for severe depression. Anesthesia and Analgesia 103, 7680.Google Scholar
Wilson, BA, Watson, PC, Baddeley, AD, Emslie, H, Evans, JJ (2000). Improvement or simply practice? The effects of twenty repeated assessments on people with and without brain injury. Journal of the International Neuropsychological Society 6, 469479.Google Scholar