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Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort

Published online by Cambridge University Press:  02 January 2007

Pilar Galan ,
Nathalie Noisette ,
Carla Estaquio ,
Sebastien Czernichow ,
Louise Mennen ,
Jean-Charles Renversez ,
Serge Briançon ,
Alain Favier  and
Serge Hercberg
Pilar Galan*
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Nathalie Noisette
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Carla Estaquio
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Sebastien Czernichow
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Louise Mennen
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
Jean-Charles Renversez
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, France
Serge Briançon
Affiliation:
Ecole de Santé Publique, Epidémiologie clinique, Faculté de Médecine, CHU Nancy EA 3444, France
Alain Favier
Affiliation:
Département de Biologie Intégrée, CHU de Grenoble, France Laboratoire Lésions des Acides Nucléiques, UMR CNRS-CEA-UJF 5046, Grenoble, France
Serge Hercberg
Affiliation:
U557 INSERM (UMR INSERM/INRA/CNAM), Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France Unité de Surveillance et d'Epidémiologie Nutritionnelle, INVS/CNAM, Paris, France
*
*Corresponding author: Email pilar.galan@cnam.fr
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Abstract

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Background

Iron has been suggested to play a role in the development of cardiovascular disease (CVD) through its pro-oxidant properties. However, epidemiological studies on iron status and the risk of CVD have yielded conflicting results. We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population.

Methods

In total, 9917 subjects (3223 men aged 45–60 years and 6694 women aged 35–60 years) included in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort were followed prospectively for 7.5 years. All cases of ischaemic heart disease (IHD) were identified and validated. CVD risk factors, haemoglobin and serum ferritin concentrations were measured at baseline.

Findings

Of men 4.3%, and of women 37.8%, presented at baseline a serum ferritin concentration <30 μg l−1. During the follow-up, 187 subjects (148 men, 39 women) developed IHD. Serum ferritin was positively associated with total cholesterol, serum triglycerides, systolic and diastolic blood pressure, body mass index and haemoglobin. No linear association was found between serum ferritin and IHD risk in men or in women.

Conclusion

Our data do not support a major role of iron status in the development of IHD in a healthy general population.

Keywords

IronSerum ferritinIschaemic heart diseaseProspective study
Type
Research Article
Information
Public Health Nutrition , Volume 9 , Issue 1 , February 2006 , pp. 70 - 74
Copyright
Copyright © The Authors 2006

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