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Health effects following long-term exposure to thorium dusts: a twenty-year follow-up study in China

Published online by Cambridge University Press:  17 June 2005

X. A. Chen ,
Y. E. Cheng ,
H. Xiao ,
G. Feng ,
Y. H. Deng ,
Z. L. Feng ,
L. Chen ,
X. M. Han ,
Y. J. Yang  and
Z. H. Dong
...Show all authors
X. A. Chen
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
Y. E. Cheng
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
H. Xiao
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
G. Feng
Affiliation:
Hospital of Baiyun Obo Rare-earth Iron Mine Baiyun Obo, Baotou 014080, P.R. China
Y. H. Deng
Affiliation:
Hospital of Baiyun Obo Rare-earth Iron Mine Baiyun Obo, Baotou 014080, P.R. China
Z. L. Feng
Affiliation:
Hospital of Baiyun Obo Rare-earth Iron Mine Baiyun Obo, Baotou 014080, P.R. China
L. Chen
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
X. M. Han
Affiliation:
Hospital of Baiyun Obo Rare-earth Iron Mine Baiyun Obo, Baotou 014080, P.R. China
Y. J. Yang
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
Z. H. Dong
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
R. Zheng
Affiliation:
National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, P.O. Box 8018, Beijing 100088, P.R. China
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Abstract

A twenty-year follow-up study was carried out at Baiyun Obo Rare-earth Iron Mine in China, This mine has been mined since 1958. Its ore contains 0.04% of ThO2 and 10% of SiO2. The purpose of this study is to investigate possible health effects in dust-exposed miners following long-term exposure to thorium-containing dusts and thoron progeny. By using the negative high voltage exhaled thoron progeny measurement system to estimate the miner’s thorium lung burden. The highest thorium lung burden among 1 158 measurements of 638 miners was 11.11 Bq. The incidence of stage 0+ pneumoconiosis was increased among dust-exposed miners. An epidemiological study showed that the lung cancer mortality of the dust-exposed miners was significantly (p < 0.005) higher than that of the non-exposed group. It is suggested that the difference results in the long-term exposure to thorium-containing dusts (carcinogens are ThO2 and SiO2) and thoron progeny. This is the first evidence in humans of the carcinogenicity after long-term inhalation of thorium-containing dusts and thoron progeny. The total person-years of observation for the dust-exposed miners and the controls were 62 712 and 34 672 respectively.

Keywords

thoriumthoron progenyhealth effectslung cancerepidemiologyChina
Type
Research Article
Information
Radioprotection , Volume 39 , Issue 4 , October 2004 , pp. 525 - 533
Copyright
© EDP Sciences, 2004

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References

Chen, X.A. (2001) A Progress Report to IAEA, Chin. J. Radiol. Health 10, 231.
Chen, X.A., Cheng, Y.E. (1989) Long-term monitoring of thorium inhaled by workers and assessment of thorium lung burden in China, Rad. Prot. Dosim. 79, 91-93.
Chen, X.A., Xiao, H.J., Cheng, Y.E., Yang Ying-jie (1995) An observation on the clearance of thorium dioxide from the lung of a miner, J. Radial. Prot. 15, 343-346.
Chen X.A., Cheng Y.E., Zhen R. (2000) Health effects following long-term exposure to thorium dusts, A fourteen-year follow-up study in China, In: Proceedings of the 10th International Congress of IRPA, Hiroshima, Japan Health Physics Society (CD-ROM) Hiroshima 2000.
Ginevan, M.E. (1981) Poisson trials approach to interpopulation comparisons of cause of death data, Environm. Reas. 25, 147-159. CrossRef
IARC (1996) Monographs on the evaluations of the carcinogenic risk of chemicals of humans, Vol. 68: Silica and Silica Compounds. CRC Press Inc.
IARC (2000) Monographs on the evaluation of carciongenic risks to humans, Vol. 78: Ionizing radiation, part 2: Some internally deposited radionuclides, p. 175. IARC Press, Lyon.
ICRP Publication 10 (1968) Evaluation of radiation doses to body tissues from internal contamination due to occupational exposure, pp. 115-120. Oxford Pergamon Press, Oxford.
ICRP Publication 10A (1975) The Assessment of internal contamination resulting from recurrent or prolonged uptakes, pp. 5-6. Oxford Pergamon Press, Oxford.
ICRP Publication 47 (1986) Radiation protection of workers in mines, Ann. ICRP 16 (1).
ICRP Publication 66 (1994) Human respiratory truct model for radiological protection, Ann. ICRP 24 (1-3).
Jarvis N.S., Birchall A., James A.C., Bailey M.R., Dorrian M.D. (1996) LUDEP 2.0 Personal Computer Program for calculating internal dose using the ICRP Publication 66 respiratory tract model, NRPB-SR287.
Li Wenyuan, Hou Qing-mei, Lu Hui-min (1988) A preliminary investigation on the AMAD values of the thorium dusts in the air of the workshops of Baiyun Obo Iron Mine, Chin. J. Rad. Med. Prot. 8, 410-413.
Liu, Z., Lee, T.S., Kotek, T. (1992) Mortality among workers in a thorium-processing plant-A second follow-up, Scand. J. Work Environm. Health 18, 162-168. CrossRef
Panomareva B.L. (1979) Long-term effect on rats of the dust radiation factor combined with chronic $\gamma$-irradiation, Industrial hygiene and professional diseases, No. 12, p. 34.
Porstendorfer, J., Mercer, T.T. (1979) Influence of electric charge humidity upon the diffusion coeffcient of radon decay products, Health Phys. 37, 191-199. CrossRef
Spiethoff A., Wesch H., Wegener K., Klimisch H.-J. (1994) Interaction of thorotrast and quartz in the induction of lung tumors in rats. Health effects of internally deposited radionuclides: Emphasis on radium and thorium, Proceedings of an international seminar held in Heidelberg, Germany, 18-21 April 1994.
Stehney A.F., Polednak A.P., Rundo J., Brues A.M., Lucas Jr H.F., Patten B.C, Rowland R.E. (1980) Health status and body radioactivity of thorium workers. interim report, Argonne National Laboratory, Argronne, Illinois, pp. 33-34.
Xu Jinkui, Zhang Jian, Chen Xing-an, (1994) An assessment of the air concentrations of radon and thoron progeny in the crushing workshop of Bayun Obo Rare-Earth Iron Mine, Chin. J. Rad. Med. Prot. 14, 185-188.