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Preclinical Alzheimer's disease

Published online by Cambridge University Press:  20 March 2014

P Gil-Gregorio  and
R Yubero-Pancorbo
P Gil-Gregorio
Affiliation:
Memory Unit, Geriatric Department, Hospital Clinico San Carlos, Madrid, Spain
R Yubero-Pancorbo*
Affiliation:
Memory Unit, Geriatric Department, Hospital Clinico San Carlos, Madrid, Spain
*
Address for correspondence: Raquel Yubero, Hospital Clínico San Carlos, Servicio de Geriatría, c/Profesor Martín Lagos, s/n 28040, Madrid, Spain. Email: raquel_yubero@hotmail.com
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Summary

Recently, diagnostic criteria for preclinical Alzheimer's disease have been proposed. These describe and define three stages of disease. Stage I is focused on asymptomatic cerebral amyloidosis. Stage II includes evidence of synaptic dysfunction and/or early degeneration. Finally, stage III of the disease is characterized by the beginning of cognitive decline.

Keywords

Alzheimer’s diseasepreclinical stagesamyloidosisneurodegenerationcognition
Type
Review Article
Information
Reviews in Clinical Gerontology , Volume 24 , Issue 2 , May 2014 , pp. 117 - 121
Copyright
Copyright © Cambridge University Press 2014 

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References

1Sperling, RA, Aisen, PS, Beckett, LAet al.Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer´s Association workgroups on diagnostic guidelines for Alzheimer's Disease. Alzheimer's Dementia 2011; 7: 280–92.CrossRefGoogle ScholarPubMed
2Jack, CR, Knopman, DS, Jagust, WJet al.Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol 2010; 9: 119–28.CrossRefGoogle ScholarPubMed
3Shaw, LM, Vanderstichele, H, Knapik-Czajla, Met al.Cerebrospinal fluid biomarkers signature in Alzheimer's disease neuroimaging initiative subjects. Ann Neurol 2009; 65: 403–13.CrossRefGoogle ScholarPubMed
4Ikonomovic, MD, Klunk, WE, Abrahamson, EEet al.Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease. Brain 2008; 131: 1630–45.CrossRefGoogle Scholar
5Mintun, M, Saha, K, Fleisher, Aet al.Florbetapir PET imaging of β amyloid plaques is highly correlated with histopathological assays at autopsy. J Nucl Med 2010; 51: abstract 387.Google Scholar
6Hample, H, Buerger, K, Zinkowsky, Ret al.Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer's disease: a comparative cerebrospinal fluid study. Arch Gen Psychiatry 2004; 61: 95–102.CrossRefGoogle Scholar
7Jagust, WJ, Landau, SM, Shaw, LMet al.Relationship between biomarkers in aging and dementia. Neurology 2009; 73: 1193–99.Google Scholar
8Dickerson, BC, Wolk, DA. MRI cortical thickness biomarkers predict AD-like CSF and cognitive decline in normal adults. Neurology 2012; 78: 84–90.CrossRefGoogle ScholarPubMed
9Becker, JA, Hedden, T, Carmasin, Jet al.Amyloid β associated cortical thinning in clinically normal elderly. Ann Neurol 2011; 69: 1032–42.Google Scholar
10Seidenberg, M, Guidotti, I, Nielson, KAet al.Semantic memory activation in individuals at risk for developing Alzheimer's disease. Neurology 2009; 73: 612–20.Google Scholar
11Fernandez, A, Turrerro, A, Zuluaga, P, Gil Gregorio, P, del Pozo, F, Maestu, F, Moratti, S. MEG delta mapping along the healthy aging-Alzheimer's disease continuum: diagnostic implications. JAD 2013; 35: 495–501.Google Scholar
12Dubois, B, Feldman, HH, Jacova, Cet al.Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol 2007; 6: 734–46.CrossRefGoogle ScholarPubMed
13Ewers, M, Insel, PS, Stern, Y, Weiner, MW. Cognitive reserve associated with FDG-PET in preclinical Alzheimer disease. Neurology 2013; 80: 1194–201.CrossRefGoogle ScholarPubMed
14Knopman, DS, Caselli, RJ. Appraisal of cognition in preclinical Alzheimer's disease: a conceptual review. Neurodegener Dis Manag 2012; 2: 183–95.Google Scholar
15Schmid, NS, Taylor, KI, Foldi, NS, Berres, M, Monsch, AU. Neuropsychological signs of Alzheimer's disease 8 years prior to diagnosis. JAD 2013; 34: 537–46.CrossRefGoogle ScholarPubMed
16Yubero, R, Salmon, D. Valoración Cognitiva en el Anciano. In Gil Gregorio, P (ed), Tratado de Neuropsicogeriatría, pp. 81–89. Sociedad Española de Geriatría y Gerontología SEGG. Madrid, Ergón; 2010.Google Scholar
17Mandal, PK, Joshi, J, Saharan, S. Visuospatial perception: an emerging biomarker for Alzheimer's disease. JAD 2013, 31 (suppl 3): S117–35.CrossRefGoogle Scholar