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The role of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) as a prognostic marker in older people: the impact of reduced renal function

Part of: Bespoke shallow archive Weizmann

Published online by Cambridge University Press:  17 September 2009

Thiane Gama Axelsson  and
Bengt Lindholm
Thiane Gama Axelsson
Affiliation:
Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
Bengt Lindholm*
Affiliation:
Divisions of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
*
Address for correspondence: Bengt Lindholm, Division of Renal Medicine K56, Karolinska University Hospital at Huddinge, 141 86 Stockholm, Sweden. Email: bengt.lindholm@ki.se
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Summary

The N-terminal pro-brain natriuretic peptide (NT-pro-BNP) is released in response to volume expansion and/or increased tension on left ventricular myocytes. NT-pro-BNP is a useful diagnostic and prognostic biomarker both in patients with dyspnoea of unknown aetiology, and for risk assessment of patients with established heart failure. However, impaired kidney function – a common condition in older people as well as a strong risk factor for cardiovascular disease is associated with elevated circulating levels of NT-pro-BNP. Therefore, it is important to know the kidney function when interpreting an elevated NT-pro-BNP measurement obtained in older people in order to diagnose or stage congestive heart failure.

Keywords

Brain natriuretic peptideolder peoplerenal functioncongestive heart failure
Type
Biological gerontology
Information
Reviews in Clinical Gerontology , Volume 19 , Issue 2 , May 2009 , pp. 71 - 76
Copyright
Copyright © Cambridge University Press 2009

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