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The case for the involvement of the Upf3p in programmed −1 ribosomal frameshifting

Published online by Cambridge University Press:  27 December 2000

JONATHAN DINMAN ,
MARIA RUIZ-ECHEVARRIA ,
WEIRONG WANG  and
STUART PELTZ
JONATHAN DINMAN
Affiliation:
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
MARIA RUIZ-ECHEVARRIA
Affiliation:
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
WEIRONG WANG
Affiliation:
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
STUART PELTZ
Affiliation:
Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
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Abstract

Translational fidelity, programmed frameshifting, and nonsense-mediated decay (NMD) may require common proteins, reflecting related events in translation and ribosome function (reviewed in Czaplinski et al., 1999). This letter focuses on the possible link between programmed frameshifting and NMD, and seeks to reconcile apparently conflicting conclusions concerning a proposed overlap in the factors involved.

Type
DIVERGENT VIEWS
Information
RNA , Volume 6 , Issue 12 , December 2000 , pp. 1685 - 1686
Copyright
© 2000 RNA Society

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