This essay examines the prospects and plans of a family of small-scale French papermakers, the Serves, from the 1780s to the 1830s. It explores the interplay of risk, the state, labor discipline, and technological diffusion. Pierre Serve petitioned the monarchy, the Revolutionary state, and the Napoleonic regime for a subsidy to install Hollander beaters, a machine that macerated rags, in his shops. His son pursued a law to humble the journeymen paperworkers, whose custom and skill continuously challenged the Serves' mastery of their mill. Timely responses from the state, which favored large producers, never came. Consequently, the Serves fell back on their own resources and the market, which determined their fate.

These introductory remarks are unorthodox in many respects. The deviance from usual practice is justified by the extreme importance I attach to the subject matter of this special issue. I want to convey to the reader a sense of why I think controversies, particularly in science, are so crucial, and to propose a different way of thinking about them. This mandates, in the limited space available, a compact presentation, omitting supporting arguments and necessary elaboration — for which the reader is referred to the bibliography.

Eugenics, in whatever form it may be articulated, is based on the idea that phenotypic characteristics of particular individuals can be predicted in advance. This paper argues that biology's capacity to predict many of the characteristics exhibited by an individual, especially behavioral or cognitive attributes, will always be very limited. This stems from intrinsic limitations to the methodology for relating genotypes to phenotypes, and from the nature of developmental processes which intervene between genotypes and phenotypes. While genetic studies may generate valid population predictions for conditions which impact human health, neither genetics nor developmental biology are likely to generate useful individual predictions about variation in non-disease-related human behavioral and cognitive phenotypes in the foreseeable future.

Controversies are pervasive in the history of science. History is thus here also at odds with science's images. According to both traditional and contemporary views of science, there are no scientific controversies sui generis. In traditional images of science controversies are external to science proper; in some contemporary views nothing about controversies in science specifically distinguishes them from controversies in other domains. According to one traditional image, science progresses from common ground to conclusions according to secure procedures such that there is no place for disagreement nor, therefore, for controversy. According to another traditional image of science, there are no such secure procedures. On the contrary: one does and even should jump to conclusions. Whereas here subsequent criticism is called for, it seems that controversy is not. This image is built on the assumption that refutations are clear cut, so that producing a valid refutation does not require a lengthy exchange of arguments.

This essay addresses the historiographical question of how to study scientific instruments and the connections between them without rigidly determining the boundaries of the object under historical scrutiny beforehand. To do this, I will explore an episode in the early history of the tachistoscope — defined, among other things, as an instrument for the brief exposure of visual stimuli in experimental psychology. After looking at the tachistoscope described by physiologist Volkmann in 1859, I will turn to the gravity chronometer, constructed by Cattell at Wundt's Leipzig institute of psychology in the 1880s. Taking Wittgenstein's notion of family resemblances as a methodological suggestion to travel from one member to another to find out just how members relate to one another, I will investigate part of the family to which both the tachistoscope and the gravity chronometer turn out to belong. A detailed analysis of these instruments, using both historical sources and historical accounts of psychological instruments, may demonstrate that the instrument is not a standard package that, if well applied, will simply secure good results. Each package needs to be assembled again and again; the particular package that is assembled may differ on different occasions. Thus an alternative is developed to an understanding of instruments as univocally functioning material means.

David Bloor often wrote that Karl Mannheim had “stopped short” in his sociology of knowledge, lacking the nerve to consider the natural sciences sociologically. While this assessment runs counter to Mannheim's own work, which responded in quite specific ways both to an encroaching “modernity” and a looming fascism, Bloor's depiction becomes clearer when considered in the light of his principal introduction to Mannheim's work — a series of essays by Robert Merton. Bloor's reading and appropriation of Mannheim emerged from his background in experimental psychology and his attempts to supercede Merton's own structural-functionalist program for the sociology of knowledge. By retracing this extended trail of readings and re-readings, we may begin to understand the roots of Bloor's curious interpretation of Mannheim's sociology of knowledge, and inquire in a reflexive way about the present and future directions of science studies.

Conflicts between scientists over credit for their discoveries are conflicts, not merely in, but of science because discovery is not a historical event, but a retrospective social judgment. There is no objective moment of discovery; rather, discovery is established by means of a hermeneutics, a way of reading scientific articles. The priority conflict between Roger Guillemin and Andrew Schally over the discovery of the brain hormone, TRF, serves as an example. The work of Robert Merton, Thomas Kuhn, Augustine Brannigan, and Grygory Markus shows that scientists read scientific articles by means of the application of a set of pragmatic rules that subtend the normative requirements of what counts as a scientific discovery. In other words, there is a hermeneutics of science, but it is internal to that form of life. Recategorization of priority conflicts has an impact on our view of scientific controversy generally. The impact is the revision of the boundary lines of scientific controversy and the further specification of its fine-structure.

This article considers three major problems with the concept of genes for human personality traits: (1) uncertainty about what human personality is; (2) what we mean when we say there is a gene “for” a mental attribute; and (3) the complexity of interactions between genes and environment, and among the genes themselves. It then draws on examples from empirical human genetic studies by the author and his colleagues in order to suggest that the concept of genes for human personality traits nevertheless does have some validity, and also that we may be on the brink of discovering genes with major effects on human personality. This possibility, in particular its ethical aspects, has aroused some public concern. It is suggested that confidential information about an individual's genes does not differ in principle from other confidential information about him or her, and that the ability (currently theoretical) to affect genes and their expression, temporarily or permanently, does not differ ethically from our current ability to affect other aspects of an individual's physical and psychological functioning. Genes for potential offspring, contained in ova and sperm cells, constitute a special case.

Michael Polanyi (1891–1976) is placed in the ongoing Enlightenment-reform tradition as one of the first twentieth-century scientists to propose a program to correct the gravest internal conflict of the modern Enlightenment project of radical criticism: scientific detachment and moral nihilism in conflict with humanist values. He held that radical criticism leads not to truth but to destructive doubt. Only the inclusion of the “personal element,” the judicial attitude of reasonable doubt and the acknowledgment of belief in the regulative principle of truth can overcome this end. Freedom — to reason, to criticize the method of doubt, and freedom of scientific thinking — is a precondition to reach truth. His epistemology of nonsubjective personal knowledge has redefined scientific knowing and objectivity as grounded in tacit knowing. Debate is continuing on objectivity and freedom versus the social duty of science. Polanyi's Hungarian correspondence highlights his commitment to truth and the contemporary cultural-political situation of Jewish intellectuals.

The purpose of this article is twofold. Firstly, I propose to analyze controversies using a “dialectical” model, in the sense described in Aristotle's Topics. This approach presupposes that we temporarily disregard, for the sake of clarity, the concreteness of real life controversies in order to focus on their argumentative structure. From this point of view, the main advantage of controversies is that they allow the interlocutors to test each other's claims and therefore to arrive at relatively corroborated conclusions. This testing function in a dialectical context is implemented through the assent to commonly accepted premises, and the necessity which characterizes each step of the reasoning.

Secondly, I shall apply this dialectical framework to the study of the controversy concerning the motion of the Earth, or rather a small episode of it. I shall examine an exchange of letters, written in 1616 and in 1624 respectively, between Galileo Galilei and Francesco Ingoli, one of his Aristotelian opponents. I shall then compare this exchange with the first day of Galileo's Dialogue Concerning the Two Chief Systems of the World (1632), a fictional debate, where Galileo discusses some of the same arguments. While the first exemplifies what I call “negative” testing, and yields a refutation of the opponent's theses, the second exemplifies “positive” testing and yields a dialectical demonstration of the motion of the Earth.

Many associations have recently been discovered between phenotypic variation and genetic loci, causing some to advocate what Robert Sinsheimer has called “a new eugenics” that would treat genetic “defects” in individuals prone to a disease. The first premise of this vision is that genetic association studies reveal the biological cause of the phenotypic variation. Once the responsible genes are known, the second premise is that we should focus upon changing “nature” rather than “nurture” by correcting the “defective” genes.

The first premise is flawed because associations between genetic markers and phenotypes can be spurious, as shown by an example. Moreover, it is shown that using non-causative but associated genetic markers one at a time (the normal practice) can lead to incorrect predictions of disease risk for many individuals. Going from association to causation is a non-trivial step scientifically that has rarely been done in much of the human genetic research.

Even when a particular locus does contribute to the phenotypic variation of interest, the first premise remains flawed because phenotypes in general arise from complex interactions among genes and between genes and environments as shown for genes associations with coronary artery disease (CAD). The ability of current molecular genetic tools to “fix” defective genotypes is extremely limited, but even if the technological problems could be overcome, the studies on CAD reveal no obvious “defective” gene to fix because the genetic effects are so context dependent (upon both other genes and environmental factors). Contrary to the second premise of the new eugenics, the more we learn about how different genotypes show variable responses to environments, the more important the environment becomes for individual treatment.

The paradigm of a “defective gene” may work for classical Mendelian genetic diseases that are due to loss-of-function mutations. However, such mutations affect only a small portion of humanity. When the focus is changed to common disease and behavioral phenotypes, the “defective gene” paradigm is biologically meaningless and often harmful when applied to individuals. Thus, even when genes clearly do influence common phenotypic variation, the premises of the “new eugenics” are biologically indefensible.

The main subject examined in this paper is Immanuel Kant's controversy with Philosophisches Magazin regarding Kant's new theory of judgments. J. A. Eberhard, editor of Philosophisches Magazin, and his colleagues wanted to vindicate the Wollfian traditional concept of judgments by undermining Kant's claims. As will be demonstrated, their arguments were effective mainly in exposing the ambiguity that was inherent in Kant's concept of the synthetic a priori; an ambiguity that resulted from Kant's desire—central to his critique of metaphysics—to present judgments pertaining to mathematics, (dogmatic) metaphysics, and pure natural science as judgments which shared a common form. Exposing this ambiguity was not the intended result, and it was insufficient for the purpose of vindicating the Wollfian tradition. The contributors to Philosophisches Magazin ignored the important properties shared by the class of judgments falling under Kant's concept of synthetic a priori judgments. They also ignored the fact that their position was unable to account for the logical phenomena that motivated Kant to present a new theory of judgments. On the other hand, Kant's theory of judgments was insensitive to the important differences that exist among the distinct types of judgments falling under his concept of a synthetic a priori judgment. This latter point is clearly shown in the controversy regarding the novelty of Kant's concept of a synthetic a priori judgment, and in the controversy regarding the function of intuitions within synthetic judgments.

A result of the controversy was that Kant's concept of the synthetic a priori, which he believed to be an exact concept, was revealed to be a metaphor: no more than an invitation to view certain intellectual fields in the light of others. On the other hand, Eberhard and his colleagues failed to come up with satisfactory answers to Kant's questions within their traditional concept of judgment. Both parties refused to acknowledge this result. Consequently, the search for a new logic, a new architectonic order, and a new unity within reason became a general problem for the new generation of philosophers.

The remarkable progress in modern genetic technology enables the identification of genes causing devastating diseases and thereby the development of tools for prenatal diagnosis and carrier detection. To implement the results of genetic research in traditional societies, where genetic diseases are more prevalent due to inbreeding, necessitates a culturally appropriate approach that also promotes traditional and societal values important to the relevant community. This paper presents our experience with implementing the results of modern genetic research among the traditional community of the Negev Bedouin of Israel. Although the benefit of using those results for the prevention of genetic diseases seems obvious, successful implementation relies on a carefully designed educational program aimed at changing culturally related attitudes and perceptions. Such a program should attend to the needs of the community and be sensitive to its traditional values.

Pressures to lower health-care costs remain an important stimulus to eugenic approaches. Prenatal diagnosis followed by abortion of affected fetuses has replaced sterilization as the major eugenic technique. Voluntary acceptance has replaced coercion, but subtle pressures undermine personal autonomy. The failure of the old eugenics to accurately predict who will have affected offspring virtually disappears when prenatal diagnosis is used to predict Mendelian disorders. However, when prenatal diagnosis is used to detect inherited susceptibilities to adult-onset, common, complex disorders, considerable uncertainty is inherent in the prediction. Intolerance and the resurgence of genetic determinism are current pressures for a eugenic approach. The increasing use of carrier screening (to identify those at risk of having affected offspring) and of prenatal diagnosis could itself generate intolerance for those who refuse the procedures. Genetic determinism deflects society from social action that would reduce the burden of disease far more than even the maximum use of eugenics.

We examine the most famous controversy between economists — the one between Thomas Robert Malthus and David Ricardo — as a means of shedding fresh light on the current debate about economic methodology. By focusing on this controversy as the primary unit of analysis, we show how methodological considerations are but one of a whole set of stratagems employed by each opponent. We argue that each opponent's preference for a particular kind of stratagem expresses his own specific scientific style (within the general scientific and cultural style of an age). We also describe a dynamic dimension of the controversy, independent of the participants' intentions. Such a dimension is analyzed in one of the “cycles” of the controversy, which begins with a well-defined issue and expands to additional topics, without reaching a “solution” of the initial issue. The Controversy, thus, does not yield a solution of a given problem nor persuasion of the adversary — its presumable aims. Rather, its “benefit” seems to lie in an unintended result — the clarification and deepening of contrasting approaches to the discipline. Insofar as the history of a discipline requires a reconstruction of such contrasts, it is indispensable that it take into account the controversies where they emerge, and view both the positive doctrines and the methodological postures of the contenders as parts of a wider framework, within which the notion of a scientific style — which this paper attempts to clarify — looms large.

Like many controversies in science, the one between Freud and Jung is overloaded with ad hominem arguments despite the incompatibility of such arguments with the pretensions of both sides to attain scientific ad rem validity. Unlike natural scientists, Freud and Jung regarded their own ad hominem arguments as relevant to general and impersonal truths. They practically legitimized such a use claiming to have a clinical basis for the rejection of the opponent's objections by a de-validating analysis of the opponent's personality as a whole. The argument of this paper is that the de-validating strategy was neither an inevitable psychological outcome of the intricate interpersonal relationships in analytic situations nor the logical consequence of any clinical or scientific psycho-analytical discovery. It followed from the epistemological invalid pretension to have a general theory of mind which could explain by mental analysis the existence of “unreasonable opinions,” and the application of the same principles to the opinion that the theory itself is unreasonable. Such a pretension, apparently specific to mystical traditions in theology and metaphysics, was deeply rooted in the modern epistemological tradition. The paper examines the impact of the different branches of that tradition on Freud and Jung's respective ideologies, theories, and practice, including the ad hominem malpractice.

Advances in genetic research make it possible to identify carriers of a growing number of genetic diseases. The World Health Organization (WHO) published several preconditions for community carrier screening. This paper aims to present some of the dilemmas about screening in Israel and the difficulties in following the WHO's helpful criteria.