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Neuropsychological Disorders Indicative of Postresuscitation Encephalopathy in Rats

Published online by Cambridge University Press:  10 April 2014

Natalia A. Gorenkova ,
Irina V. Nazarenko ,
Aleksandr V. Volkov ,
Maria Sh. Avruschenko ,
Gennady B. Lapa ,
Georgi I. Kovalev  and
Lidia V. Molchanova
Natalia A. Gorenkova*
Affiliation:
Institute of General Reanimatology, Russian Academy of Sciences, Moscow
Irina V. Nazarenko
Affiliation:
Institute of General Reanimatology, Russian Academy of Sciences, Moscow
Aleksandr V. Volkov
Affiliation:
Institute of General Reanimatology, Russian Academy of Sciences, Moscow
Maria Sh. Avruschenko
Affiliation:
Institute of General Reanimatology, Russian Academy of Sciences, Moscow
Gennady B. Lapa
Affiliation:
Institute of Pharmacology, Russian Academy of Sciences, Moscow
Georgi I. Kovalev
Affiliation:
Institute of Pharmacology, Russian Academy of Sciences, Moscow
Lidia V. Molchanova
Affiliation:
Institute of General Reanimatology, Russian Academy of Sciences, Moscow
*
Address correspondence to: Natalia Gorenkova, Research Institute of General Reanimathology, Russian Academy of Medical Sciences, Laboratory of General Pathology, Petrovka Str. 25/2, 103031, Moscow, Russia. Phone: 007-095-2002910 Fax: 007-095-2002708 E-mail: nat-gor@mail.ru
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Abstract

The aim of this research was to study the effect of 12-minute clinical death on innate and acquired behavior, biogenic amine concentration, and the composition and quantity of neural populations in specific brain regions of white rats. The study shows that in animals during the postresuscitation period with formal restoration of neurological status, there are changes in emotional reactivity, orientation-exploration reactions, impairment of learning and memory, decrease in exercise tolerance and pain sensitivity. These processes are accompanied by alterations in serotonin and norepinephrine levels in the frontal cerebral cortex, dopamine and serotonin levels in the striatum, certain biochemical indices in blood plasma and neural loss in the CA1 sector of the hippocampus and lateral portions of the cerebellum.

El propósito de este estudio fue examinar el efecto de una muerte clínica de 12 minutos de duración sobre el comportamiento innato y adquirido, la concentración amino biogénica, y la composición y cantidad de las poblaciones neuronales en regiones específicas en ratas blancas. El estudio muestra que durante el período con restauración formal del estatus neurológico, hay cambios en los animales en la reactividad emocional, las reacciones de orientación-exploración, trastornos de aprendizaje y memoria, reducción de la tolerancia al ejercicio y la sensibilidad al dolor. Estos procesos se acompañan de alteraciones en los niveles de serotonina y norepinefrina en la corteza cerebral frontal, en los niveles de dopamina y serotonina en el cuerpo estriado, ciertos índices bioquímicos en el plasma sanguíneo y pérdida neuronal en el sector CA1 del hipocampo y en porciones laterales del cerebelo.

Keywords

neuropsychological disordersclinical deathpostresuscitation encephalopathyemotional reactivityorientation-exploration reactionbiogenic aminesneuronal populationtrastornos neuropsicológicosmuerte clínicaencefalopatía post-reanimaciónreactividad emocionalreacción orientación-exploraciónaminas biogénicaspoblacion neuronal
Type
Articles
Information
The Spanish Journal of Psychology , Volume 8 , Issue 2 , November 2005 , pp. 246 - 255
Copyright
Copyright © Cambridge University Press 2005

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