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An EEG Measure of the Effect of Mood Change on the Thiopentone Tolerance of Depressed Patients

Published online by Cambridge University Press:  29 January 2018

George W. Fenton ,
Denis Hill  and
Leila Scotton
George W. Fenton
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
Denis Hill
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
Leila Scotton
Affiliation:
Academic Department of Psychiatry, Middlesex Hospital Medical School, London, W.1
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Extract

It is a common clinical observation that emotional disturbance can influence a patient's response to sedative drugs. In recent years these effects have been studied in both normal and emotionally ill subjects. Kornetsky and Humphries (1957) found that in ten healthy adults the response to small doses of secobarbital sodium correlated with the scores on the depression and psychasthenia scales of the MMPI. Von Felsinger et al. (1955), in a study of the effect of a variety of psychotropic drugs, including pentobarbitone, on “normal” subjects, observed that those who responded in an atypical fashion tended to have abnormal personalities and to suffer from depressive episodes. Beecher (1955) has pointed out that the degree of placebo effect on post-operative analgesia varies with the severity of the stress to which the patient is exposed.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 114 , Issue 514 , September 1968 , pp. 1141 - 1147
Copyright
Copyright © Royal College of Psychiatrists, 1968 

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