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Autosomal Dominant Gene Transmission in a Large Kindred with Gilles de la Tourette Syndrome

Published online by Cambridge University Press:  02 January 2018

David Curtis ,
Mary M. Robertson  and
Hugh M. D. Gurling
David Curtis
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
Mary M. Robertson
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
Hugh M. D. Gurling*
Affiliation:
Academic Department of Psychiatry, University College & Middlesex School of Medicine, Middlesex Hospital, Riding House Street, London W1P 7PN
*
∗Correspondence
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Abstract

A multiplex kindred ascertained through a single proband with GTS has been systematically investigated with standardised diagnostic instruments for other cases of GTS and related disorders. Complex segregation analysis supported the hypothesis that a single major gene inherited in autosomal dominant fashion but with incomplete penetrance contributed most of the variance in the liability to develop GTS and related disorders. This result is consistent with previous segregation analyses which have employed different methods of ascertainment, and tends to confirm that a proportion of GTS is due to a dominant gene and is suitable for investigation with genetic markers for linkage analysis.

Type
Papers
Information
The British Journal of Psychiatry , Volume 160 , Issue 6 , June 1992 , pp. 845 - 849
Copyright
Copyright © The Royal College of Psychiatrists 

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