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A Case of Tranylcypromine (‘Parnate’) Addiction

Published online by Cambridge University Press:  29 January 2018

O. Ben-Arie  and
G. C. W. George
O. Ben-Arie
Affiliation:
Department of Psychiatry, University of Cape Town and Groote Schuur Hospital, Cape Town, Republic of South Africa
G. C. W. George
Affiliation:
Department of Psychiatry, University of Cape Town and Groote Schuur Hospital, Cape Town, Republic of South Africa
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Summary

A case of addiction to tranylcypromine is described where tolerance occurred and a severe withdrawal illness followed discontinuation of the drug. Previous reports in the literature of similar cases are reviewed and comparisons made, and the implications for management are discussed.

Type
Case Report
Information
The British Journal of Psychiatry , Volume 135 , Issue 3 , September 1979 , pp. 273 - 274
Copyright
Copyright © Royal College of Psychiatrists, 1979 

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References

Bandt, C. & Hoffbauer, F. W. (1964) Liver injury associated with tranylcypromine therapy. Journal of the American Medical Association, 188, 752.Google Scholar
Klein, D. F. & Davis, J. M. (1969) Diagnosis and Drug Treatment of Psychiatric Disorders. Baltimore: Williams and Wilkins.Google Scholar
Le Gassicke, J. (1963) Tranylcypromine. The Lancet, i, 270.Google Scholar
Le Gassicke, J., Ashcroft, G. W., Eccleston, D., Evans, J. I., Oswald, I. & Ritson, E. B. (1965) The clinical state, sleep and amine metabolism of a tranylcypromine (Parnate) addict. British Journal of Psychiatry, 111, 357–64.Google Scholar
Mielczarek, J. & Johnson, J. (1963) Tranylcypromine. The Lancet, i, 388–9.Google Scholar
Pitt, B. (1974) Withdrawal symptoms after stopping phenelzine? British Medical Journal, ii, 332–3.Google Scholar
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