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The Effect of Long Term Phenothiazine Therapy on Plasma Prolactin

Published online by Cambridge University Press:  29 January 2018

R. G. Wilson ,
J. R. Hamilton ,
W. D. Boyd ,
A. P. M. Forrest ,
E. N. Cole ,
A. R. Boyns  and
K. Griffiths
R. G. Wilson
Affiliation:
Department of Surgery, General Hospital, Nottingham
J. R. Hamilton
Affiliation:
University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh
W. D. Boyd
Affiliation:
Royal Edinburgh Hospital, Morningside Park, Edinburgh
A. P. M. Forrest
Affiliation:
University Department of Clinical Surgery, Royal Infirmary, Edinburgh
E. N. Cole
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
A. R. Boyns
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
K. Griffiths
Affiliation:
Tenovus Institute for Cancer Research, Cardiff
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Summary

Plasma prolactin has been estimated in 69 psychiatric in-patients receiving either thioridazine (20–300 mg./day) or chlorpromazine (50–200 mg./day) or other phenothiazines. A homologous radioimmuno-assay was used which depends on an antiserum to human amniotic prolactin. Prolactin levels were significantly increased in these patients compared with control patients, and were dose related. Simultaneous estimation of growth hormone revealed normal levels.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 127 , Issue 1 , July 1975 , pp. 71 - 74
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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References

Apostolakis, M., Kapetanakis, S., Lazos, G. & Madena-Pyrgaki, A. (1972) Plasma prolactin activity in patients with galactorrhoea after treatment with psychotropic drugs. In Lactogenic Hormone. (eds. Wolstenholme, G. E. W. and Knight, J.), pp. 349–54. Edinburgh and London: Churchill Livingstone.Google Scholar
Beumont, P. J. V., Gelder, M. G., Mandelbrote, B. M., Wiles, D. W., Friesen, H. G., Harris, G. W. & Mackinnon, P. C. B. (1974) The effects of phenothiazines on endocrine function; patients with inappropriate lactation and amenorrhoea. British Journal of Psychiatry, 124, 413–9.CrossRefGoogle Scholar
Boyns, A. R., Buchan, R., Cole, E., Forrest, A. P. M. & Griffiths, K. (1973a) Basal prolactin blood levels in three strains of rat with different incidence of 7, 12-dimethyl-benzanthracene induced mammary tumours. European Journal of Cancer, 9, 169–71.Google Scholar
Boyns, A. R., Cole, E. N., Griffiths, K., Roberts, M. M., Buchan, R., Wilson, R. G. & Forrest, A. P. M. (1973b) Plasma prolactin in breast cancer. European Journal of Cancer, 9, 99–102.CrossRefGoogle ScholarPubMed
Bryant, G. D. & Greenwood, F. C. (1972) The concentrations of human prolactin in plasma measured by radioimmuno-assay; experimental and physiological modifications. In Lactogenic Hormone. (eds. Wolstenholme, G. E. W. and Knight, J.), pp. 197–206. Edinburgh and London: Churchill Livingstone.Google Scholar
Cole, E. N. & Boyns, A. R. (1973) Radioimmuno-assay for human pituitary prolactin using antiserum against an extract of human amniotic fluid. Hormone Research, 4, 261–73.CrossRefGoogle Scholar
Frantz, A. G., Kleinberg, D. L. & Noel, G. L. (1972) Studies on prolactin in man. Recent Progress in Hormone Research, 28, 527–73.Google ScholarPubMed
Hooper, J. H., Welch, V. C. & Shackelford, R. T. (1961) Abnormal lactation associated with tranquilizing drug therapy. Journal of the American Medical Association, 178, 506–7.Google ScholarPubMed
Katz, J., Kunofski, S., Patton, R. E., Alloway, N. C. (1967) Cancer mortality among patients in New York mental hospitals. Cancer, 20, 2194–9.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Nokin, J., Vekemans, M., L'Hermite, M. & Robyn, C. (1972) Circadian periodicity of serum prolactin concentration in man. British Medical Journal, iii, 561–2.Google Scholar
Palmer, J. & Maurer, L. H. (1972) Prolactin and breast cancer. Lancet, ii, 1036.CrossRefGoogle Scholar
Pearson, O. H., Murray, R. L. M., Mozaffarian, G. & Pensky, J. (1972) Prolactin and experimental breast cancer. In Prolactin and Carcinogenesi. (eds. Boyns, A. R. and Griffiths, K.), pp. 154–7. Cardiff: Alpha Omega Alpha Publishing.Google Scholar
Sassin, J. F., Frantz, A. G., Weitzman, E. D. & Kapin, S. (1972) Human prolactin: 24 hr. pattern with increased release during sleep. Science, 177, 1205–7.CrossRefGoogle Scholar
Schalch, D. S. & Parker, M. L. (1964) A sensitive double antibody immunoassay for human growth hormone in plasma. Nature, 203, 1141–2.CrossRefGoogle ScholarPubMed
Sulman, F. G. & Winnik, H. Z. (1956) Hormonal effects of chlorpromazine. Lancet, i, 161–2.Google Scholar
Wilson, R. G., Buchan, R., Roberts, M. M., Boyns, A. R., Cole, E. N., Griffiths, K. & Forrest, A. P. M. (1974) Plasma prolactin and breast cancer. Cancer, 33, 1325–7.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
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