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The Effects of Tianeptine and other Antidepressants on a Rat Model of Depression

Published online by Cambridge University Press:  06 August 2018

G. Curzon ,
G. A. Kennett ,
G. S. Sarna  and
P. S. Whitton
G. Curzon
Affiliation:
Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG
G. A. Kennett
Affiliation:
Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG
G. S. Sarna
Affiliation:
Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG
P. S. Whitton
Affiliation:
Department of Neurochemistry, Institute of Neurology, Queen Square, London WC1N 3BG
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Extract

A model of depression based on measurements made after restraining rats for two hours has been developed. The model is associated with elevation in corticosterone, reflects the higher incidence of depression in women, and shows increased post-synaptic 5-HT function with adaptation. The effects of tianeptine and other antidepressants on the model were studied. Chronic pre-treatment with desipramine, sertraline (amine uptake inhibitors), and chlordiazepoxide normalised open field activity after restraint. Single high doses, post-restraint, of 8-OH-DPAT, gepirone (5-HT agonists), and tianeptine normalised open field activity, whereas desipramine, chlordiazepoxide, and diazepam did not. It is of considerable interest that tianeptine decreased the availability of 5-HT to receptors.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 160 , Issue S15: Stress, Serotonin and Tianeptine , February 1992 , pp. 51 - 55
Copyright
Copyright © The Royal College of Psychiatrists 

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