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Familial Manic–Depressive Illness with Deleted Short Arm of Chromosome 21: Coincidental or Causal?

Published online by Cambridge University Press:  02 January 2018

Magda H. El-Badramany*
Affiliation:
Kuwait Medical Genetics Centre
Talaat I. Farag
Affiliation:
Kuwait Medical Genetics Centre
Sadika A. Al-Awadi
Affiliation:
Kuwait Medical Genetics Centre
Ibtisam M. Hammad
Affiliation:
Gynaecologist and Obstetrician, Maternity Hospital, Kuwait
Ahmed Abdelkader
Affiliation:
Gynaecologist and Obstetrician, Maternity Hospital, Kuwait
D. S. Krishna Murthy
Affiliation:
Gujarat University, Ahmedabad, India
*
Psychological Medicine Hospital, PO Box 4081, Safat, 13041, Kuwait

Abstract

A 35-year-old Arab lady and her mother, both with bipolar manic-depressive illness and 46,XX,21p-(pcenåpter), are reported. The clinical significance of this association is considered.

Type
Brief Reports
Copyright
Copyright © The Royal College of Psychiatrists, 1989 

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References

Ballantyne, G. H., Parslow, M. I., Veale, A. M. O., et al (1976) Down's syndrome and deletion of short arms of a G chromosome. Journal of Medical Genetics, 13, 147151.Google Scholar
Cook, E. H. & Levanthal, B. L. (1987) Down's syndrome with mania. British Journal of Psychiatry, 150, 249250.Google Scholar
Cook, E. H. & Levanthal, B. L. (1988) Down's syndrome and mania. British Journal of Psychiatry, 152, 721722.CrossRefGoogle Scholar
Endicott, J. & Spitzer, R. L. (1979) Use of the research diagnostic criteria and the schedule for affective disorders and schizophrenia to study affective disorders. American Journal of Psychiatry, 136, 5256.Google ScholarPubMed
Hsu, L. Y. F., Kaffe, S., Alonso, M. L., et al (1987) Frequency of deletion of the short arm in acrocentric chromosomes and its significance. American Journal of Human Genetics, 41, A123 (abstract).Google Scholar
McKusick, V. A. (1988) Catalogue of Mendelian Inheritance in Man (8th edn). Baltimore: The John Hopkins University Press.Google Scholar
McLaughlin, M. M. (1987) Bipolar affective disorder in Down's syndrome. British Journal of Psychiatry, 151, 116117.Google Scholar
Murray, R. M. & McGuffin, P. (1988) Genetic aspects of mental disorders. In Companion to Psychiatric Disorders (eds Kendell, R. E. & Zealley, A. K.), pp. 161190. Edinburgh: Churchill Livingstone.Google Scholar
Nielsen, J., Freidrich, V. & Hreidasson, A. B. (1974) Frequency of deletion of short arms of satellites in acrocentric chromosomes. Journal of Medical Genetics, 11, 177180.Google Scholar
Rorthere, M. O. (1981) Structural variations of chromosome 21 and symptoms of Down's syndrome in trisomy–21. In Trisomy 21 (eds Burgids, R., Fraccaro, M., Tipedo, L. & Wolf, V.), pp. 173182. Berlin: Springer Verlag.Google Scholar
Say, B., Carpenter, N. J., Lanier, P. R. et al (1977) Chromosome variants in children with psychiatric disorders. American Journal of Psychiatry, 134, 424426.Google Scholar
Singh, I. (1988) Down's syndrome with mania. British Journal of Psychiatry, 153, 406.Google Scholar
World Health Organization (1978) Mental Disorders: Glossary and Guide to their Classification in Accordance with Ninth Revision of the International Classification of Diseases (ICD–9). Geneva. WHO.Google Scholar
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