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Family History and Cerebral Ventricular Enlargement in Schizophrenia

A Case Control Study

Published online by Cambridge University Press:  02 January 2018

Michael J. Owen ,
Shôn W. Lewis  and
Robin M. Murray
Michael J. Owen*
Affiliation:
Department of Biochemistry and Molecular Genetics, St Mary's Hospital Medical School, London
Shôn W. Lewis
Affiliation:
Institute of Psychiatry
Robin M. Murray
Affiliation:
Institute of Psychiatry
*
∗The Genetics Section, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
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Abstract

Ventricular size was measured from CT scans in 48 patients meeting RDC for schizophrenia who had a first-degree relative with a history of treatment for major psychiatric disorder, in 48 age- and sex-matched schizophrenic patients with no such history in first- or second-degree relatives, and in 48 matched, healthy controls. There was no difference in ventricular size between those with and without a positive family history, although both groups showed ventricular enlargement with respect to normal controls. Ventricular enlargement was demonstrated in the subgroup of 23 patients with a family history of schizophrenia, but not in the subgroup of 18 patients with a family history of affective disorder. These observations provide further evidence that schizophrenics with a family history of affective disorder may constitute an aetiologically distinct subgroup.

Type
Papers
Information
The British Journal of Psychiatry , Volume 154 , Issue 5 , May 1989 , pp. 629 - 634
Copyright
Copyright © Royal College of Psychiatrists, 1989 

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