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Long-Term Monitoring of Tricyclic Antidepressant Plasma Concentrations

Published online by Cambridge University Press:  29 January 2018

Agrégé Henry Loo ,
Kader Benyacoub ,
Vincenzo Rovei ,
Carlo A. Altamura ,
Marthe Vadrot  and
Paolo L. Morselli
Agrégé Henry Loo
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Rue Cabanis, 75674 Paris Cedex 14, France
Kader Benyacoub
Affiliation:
Service Hospitalo-Universitaire de Santé Mentale et de Thérapeutique, Rue Cabanis, 75674 Paris Cedex 14, France
Vincenzo Rovei
Affiliation:
Department of Clinical Research, Synthelabo-L.E.R.S., 31 Avenue Paul Vaillant Couturier, 92220 Bagneux, France
Carlo A. Altamura
Affiliation:
Department of Psychiatry, University of Milan Medical School, Italy
Marthe Vadrot
Affiliation:
Department of Clinical Research, Synthelabo-L.E.R.S., 58 Rue de la Glacière, 75013 Paris, France
Paolo L. Morselli
Affiliation:
Department of Clinical Research, Synthelabo-L.E.R.S., 58 Rue de la Glacière, 75013 Paris, France
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Summary

Plasma levels of antidepressant drugs were measured in 17 depressed patients at roughly monthly intervals over follow-up periods of three to 26 months. Good results in seven were associated with small fluctuations in level from visit to visit, while big fluctuations were associated with poor outcome. Such fluctuations were probably from poor compliance or drug interaction from self-medication. Severe side effects and cardiotoxicity were associated with high levels.

Information

Type
Research Article
Information
The British Journal of Psychiatry , Volume 137 , Issue 5 , November 1980 , pp. 444 - 451
Copyright
Copyright © Royal College of Psychiatrists, 1980 

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References

Angst, J. & Rothweiler, R. (1973) Blood levels and clinical effects of maprotiline (Ludiomil). A preliminary study in Classification and Prediction of Outcome of Depression. Symposia Medica Hoechst 8, Schattauer Stuttgart, 237.Google Scholar
Åsberg, M., Cronholm, B., Sjoqvist, F. & Tuck, D. (1971) Relationship between plasma level and therapeutic effect of nortriptyline. British Medical Journal, iii, 331–4.Google Scholar
Braithwaite, R. A., Goulding, R., Theano, G., Bailey, J. & Coppen, A. (1972) Plasma concentration of amitriptyline and clinical response. Lancet, i, 1297–300.Google Scholar
Burrows, G., Turecek, L. R., Davies, B., Mowbray, R. & Scoggins, B. A. (1974) A sequential trail comparing two plasma levels of nortriptyline. Australian and New Zealand Journal of Psychiatry, 8, 21–3.Google Scholar
Burrows, G. D., Vohra, J. & Hunt, D. (1976) Caridac effects of different tricyclic antidepressant drugs. British Journal of Psychiatry, 129, 335–41.Google Scholar
Coppen, A. et al (1978) Amitriptyline plasma-concentration and clinical effect. Lancet, i, 63–6.Google Scholar
Gatattini, S. & Morselli, P. L. (1975) Monitoring plasma levels of tricyclic antidepressant agents: An individualized approach to depression therapy in Physician's Guide to Depression (ed. R. D. Fieve). New York: P. W. Communications Inc. Publ., 101–31.Google Scholar
Glassman, A. H., Perel, M. J., Shostak, M., Kantor, S. J. & Fleiss, J. L. (1977) Clinical implications of imipramine plasma levels for depressive illness. Archives of General Psychiatry, 34, 197–204.Google Scholar
Kantor, S. J., Glassman, A. H., Bigger, T. J., Perel, J. M. & Giardina, E. V. (1978) The cardiac effects of therapeutic plasma concentrations of imipramine. American Journal of Psychiatry, 135, 534–8.Google Scholar
Koch-Weser, J. (1972) Serum drug concentrations as therapeutic guide. New England of Medicine, 287, 227–31.Google Scholar
Kragh-Sørensen, P. (1978) Correlation between plasma levels of nortriptyline and clinical effects. Psychopharmacology, 2, 451–6.Google Scholar
Kragh-Sørensen, P., Asberg, M. & Eggert-Hansen, C. (1973) Plasmanortriptyline levels in endogenous depression. Lancet, i, 113–5.Google Scholar
Kragh-Sørensen, P., Eggert-Hansen, C., Larsen, N. E., Naestoft, J. & Hvidberg, E. F. (1974) Long-term treatment of endogenous depression with nortriptyline with control of plasma levels. Psychological Medicine, 4, 174–80.Google Scholar
Kupfer, D. J., Hanin, I., Spiker, D. G., Grau, T. & Coble, P. (1977) Amitriptyline plasma levels and clinical response in primary depression. Clinical Pharmacology and Therapeutics, 22, 904–11.Google Scholar
Montgomery, S. A., Braithwaite, R. A. & Crammer, J. L. (1977) Routine nortriptyline levels in treatment of depression. British Medical Journal, ii, 166–7.Google Scholar
Montgomery, S. A., Braithwaite, R. A., Dawling, S. & McAuley, R. (1978) High plasma nortriptyline levels in the treatment of depression. Clinical Pharmacology and Therapeutics, 23, 309–14.Google Scholar
Morselli, P. L. (1978) Clinical significance of monitoring plasma levels of benzodiazepine tranquillizers and antiepileptic drugs in Neuropsychopharmacology (eds. P. Deniker, C. Radouco-Thomas and A. Villeneuve). Oxford: Pergamon Press, 877–88.Google Scholar
Morselli, P. L. (1979) Introductory remarks on biological monitoring of psychotropic drug treatment in Neuropsychopharmacology (eds. B. Saletu, P. Berner and L. Hollister). Oxford: Pergamon Press, 555–8.Google Scholar
Morselli, P. L., Cuche, E. & Zarifian, E. (1978) Pharmacokinetics of psychotropic drugs in the paediatric patient. Advances in Biological Psychiatry, 2, 70–86.Google Scholar
Penry, J. K. & Newmark, M. E. (1979) The use of antiepileptic drugs. Annals of Internal Medicine, 90, 207–18.CrossRefGoogle ScholarPubMed
Perel, J. M., Stiller, R. L. & Glassman, A. H. (1978) Studies on plasma level/effect relationships in imipramine therapy. Psychopharmacology, 2, 429–39.Google Scholar
Robinson, D. S. & Nies, A. (1978) Antidepressant drug levels and clinical response. Lancet, ii, 100.Google Scholar
Rovei, V., Sanjuan, M. & Hrdina, P. D. (1980) Analysis of tricyclic antidepressant drugs by gas chromatography using nitrogen selective detection with packed and capillary columns. Journal of Chromatography, 182, in press.Google Scholar
Shepherd, G. A. A. & Kerr, F. (1978) Maprotiline hydrochloride and grand-mal seizures. British Medical Journal, i, 1523.Google Scholar
Sørensen, B., Kragh-Sørensen, P., Larsen, N. E. & Hvidberg, E. F. (1978) The practical significance of nortriptyline plasma control. Psychopharmacology, 59, 35–9.Google Scholar
Vohra, J., Burrows, G. D. & Sloman, G. (1975) Assessment of cardiovascular side-effects of therapeutic doses of tricyclic antidepressant drugs. Australian and New Zealand Journal of Medicine, 5, 7–11.Google Scholar
Ziegler, V. E., Co, B. T. & Biggs, J. T. (1977) Electrocardiographic findings in patients undergoing amitriptyline treatment. Diseases of the Nervous System, 38, 697–9.Google Scholar
Ziegler, V. E., Co, B. T., Taylor, J. R., Clayton, P. J. & Biggs, J. T. (1976) Amitriptyline plasma levels and therapeutic response. Clinical Pharmacology and Therapeutics, 19, 795–801.Google Scholar
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