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Midsagittal Magnetic Resonance Imaging of Autism

Published online by Cambridge University Press:  02 January 2018

Gary R. Gaffney ,
Samuel Kuperman ,
Luke Y. Tsai ,
Susan Minchin  and
Khatab M. Hassanein
Gary R. Gaffney*
Affiliation:
College of Health Sciences and Hospital, The University of Kansas
Samuel Kuperman
Affiliation:
College of Medicine, The University of Iowa
Luke Y. Tsai
Affiliation:
College of Health Sciences and Hospital, The University of Kansas
Susan Minchin
Affiliation:
College of Medicine, The University of Iowa
Khatab M. Hassanein
Affiliation:
College of Health Sciences and Hospital, The University of Kansas
*
College of Health Sciences and Hospital, The University of Kansas, Kansas City, Kansas 66103, USA
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Abstract

Since recent reports suggest structural brain abnormalities in autistic patients, we analysed magnetic resonance imaging (MAI) scans of autistic children. Planimetric measurements were done on midsagittal MRI scans, produced with a 0.5 T superconducting magnet. Scans of 13 ‘high-level’ austic subjects were compared with 35 control MRI scans, read as anatomically normal by a neuroradiologist. Corpus callosal, fourth ventricular, cerebellar, cerebral, and cranial areas were measured. The fourth ventricle was found to be significantly larger in the autistic group. No other areas in the midsagittal scans differed statistically between groups. Results suggest that structures defining the fourth ventricle are anatomically altered in autistic patients.

Type
Papers
Information
The British Journal of Psychiatry , Volume 151 , Issue 6 , December 1987 , pp. 831 - 833
Copyright
Copyright © Royal College of Psychiatrists, 1987 

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References

Bauman, M. & Kemper, T. L. (1985) Histoanatomic observations of the brain in early infantile autism. Neurology 35, 866–874.Google Scholar
Bauman, M., Kemper, T. L., M. L., Lemay, M., Bauman, R. A. & Rosenberger, P. B. (1985) Computerized tomographic (CT) observations of the posterior fossa in early infantile autism. Neurology, 35, 247.Google Scholar
Campbell, M., Rosenbloom, S., Perry, R., George, A. E., Kricheff, I. I., Anderson, L., Small, A. M. & Jennings, S. J. (1982) Computerized axial tomography in autistic children. American Journal of Psychiatry, 139, 510–512.Google ScholarPubMed
Caparulo, B. K., Cohen, D. J., Rothman, S. L., Young, J. G., Katz, J. D., Shaywitz, S. E. & Shaywitz, B. A. (1981) Computed tomographic brain scanning in children with developmental neuropsychiatric disorders. Journal of the American Academy of Child Psychiatry, 20, 338–357.CrossRefGoogle ScholarPubMed
Creasey, H., Rumsey, J. M., Schwartz, M., Duara, R., Rapoport, J. L. & Rapoport, S. I. (1986) Brain morphometry in autistic men as measured by volumetric computed tomography. Archives of Neurology, 43, 669–672.Google Scholar
Damasio, H., Maurer, R. G., Damasio, A. R. & Chui, H. C. (1980) Computerized tomographic scan findings in patients with autistic behavior. Archives of Neurology, 37, 504–510.CrossRefGoogle ScholarPubMed
Gillberg, C. & Svendsen, P. (1983) Childhood psychosis and computed tomographic brain scan findings. Journal of Autism and Developmental Disorders, 13, 19–32.CrossRefGoogle ScholarPubMed
Harcherik, D. F., Cohen, D. J., Ort, S., Paul, R., Shaywitz, B. A., Volkmar, F. R., Rothman, S. L. G. & Leckman, J. F. (1985) Computed tomographic brain scanning in four neuropsychiatric disorders of childhood. American Journal of Psychiatry, 142, 731–734.Google ScholarPubMed
Hauser, S. L., Delong, G. R. & Rosman, N. P. (1975) Pneumographic findings in the infantile autism syndrome. Brain, 98, 667–688.CrossRefGoogle ScholarPubMed
Ornitz, E. M. (1985) Neurophysiology of infantile autism. Journal of the American Academy of Child Psychiaty, 24, 251–262.Google Scholar
Prior, M. R., Tress, B., Hoffman, W. L. & Boldt, D. (1984) Computed tomographic study of children with classic autism. Archives of Neurology, 14, 482–484.Google Scholar
Ritvo, E. R., Freeman, B. J., Scheibel, A. B. et al (1986) Lower Purkinje cell counts in the cerebella of four autistic subjects: initial findings of the UCLA-NSAC autopsy research report. American Journal of Psychiatry, 143, 862–866.Google Scholar
Rosenbloom, S., Campbell, M., George, A. E., Kricheff, I. I., Taleporos, E., Anderson, L., Reuben, R. N. & Korein, J. (1984) High resolution CT scanning in infantile autism: a quantitative approach. Journal of the American Academy of Child Psychiatry, 23, 72–77.Google Scholar
Williams, R. S., Hauser, S. L., Purpura, D. P., Delong, G. R., & Swisher, C. N. (1980) Autism and mental retardation. Archives of Neurology, 37, 749–753.Google Scholar
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