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Plasma Levels of Imipramine and Desmethylimipramine during Therapy

Published online by Cambridge University Press:  29 January 2018

J. P. Moody ,
A. C. Tait  and
A. Todrick
J. P. Moody
Affiliation:
Department of Clinical Research, Crichton Royal, Dumfries; Royal Dundee Liff Hospital, by Dundee
A. C. Tait
Affiliation:
Crichton Royal, Dumfries
A. Todrick
Affiliation:
Crichton Royal, Dumfries
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Extract

Individual variations in drug metabolism are important factors affecting both toxicity and clinical effectiveness (Brodie, 1964; Kalow, 1965; Price Evans, 1965). In most cases the best available index of the drug concentration at the site of action is the plasma level. An estimate of this will show whether the optimal concentration is present and in some cases may indicate whether new symptoms can be attributed to toxic side reactions.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 495 , February 1967 , pp. 183 - 193
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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