Hostname: page-component-586b7cd67f-vdxz6 Total loading time: 0 Render date: 2024-11-22T13:03:41.388Z Has data issue: false hasContentIssue false
  • English
  • Français

Should Plasma or Urinary MHPG be Measured in Psychiatric Research? A Critical Comment

Published online by Cambridge University Press:  29 January 2018

J. G. Filser ,
W. E. Müller  and
H. Beckmann
J. G. Filser
Affiliation:
Psychopharmacological Laboratory
W. E. Müller*
Affiliation:
Psychopharmacological Laboratory
H. Beckmann
Affiliation:
Psychiatric Clinic. Present appointment: Psychiatric Clinic, University of Würzburg, D-8700 Würzburg; Central Institute of Mental Health, D-6800 Mannheim, Federal Republic of Germany
*
Correspondence
Get access Rights & Permissions [Opens in a new window]

Extract

Many experimental findings suggest that disturbances of noradrenergic neurons in the CNS are involved in the pathogenesis of depressive disorders. Moreover, evidence indicates that adaptive changes of central noradrenergic neurons contribute to the biochemical mechanism of action of most anti-depressive treatments (Goodwin, 1984; Johnstone, 1982). Accordingly, assessing the activity of central noradrenergic neurons in depressive patients has become important in psychiatric research.

Type
Comment
Information
The British Journal of Psychiatry , Volume 148 , Issue 1 , January 1986 , pp. 95 - 97
Copyright
Copyright © 1986 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Blomberry, P. A., Kopin, I. J., Gordon, E. K., Markey, S. P. & Ebert, M. H. (1980) Conversion of MHPG to vanillyl-mandelic acid. Archives of General Psychiatry, 37, 1095–1098.Google Scholar
Charney, D. S., Henninger, G. R., Sternberg, D. E., Hafstad, K. M., Giddings, S. & Landis, D. H. (1982) Adrenergic receptor sensitivity in depression. Archives of General Psychiatry, 39, 290–294.Google Scholar
Goodwin, F. K. (1984) The biology of depression: Some conceptual issues, In Frontiers in Biochemical and Pharmacological Research in Depression, eds. Usdin, E., Åsberg, M., Bertilsson, L. & Sjöqvist, F. New York, Raven Press.Google Scholar
Jimerson, D. C., Insel, T. R. Reus, V. I. & Kopin, I. J. (1983) Increased plasma MHPG in dexamethasone-resistant depressed patients. Archives of General Psychiatry, 40, 173–176.CrossRefGoogle ScholarPubMed
Johnstone, E. C. (1982) Affective disorders In Disorders of Neurohumoural Transmission, ed. Crow, T. J., London: Academic Press.Google Scholar
Kopin, I. J., Jimerson, D. C., Markey, S. P., Ebert, M. H. & Polinsky, R. J. (1984a) Disposition and metabolism of MHPG in humans: Applications to studies in depression. Pharmacopsychiatry, 17, 3–8.Google Scholar
Kopin, I. J., Blomberry, P., Ebert, M. H., Gordon, E. K., Jimerson, D. C., Markey, S. P. & Polinsky, R. J. (1984b) Disposition and metabolism of MHPG-CD3, in humans. Plasma MHPG as the principal pathway of norepinephrine metabolism and as important determinant of CSF levels in MHPG In Frontiers in biochemical and pharmacological research in depression, eds. Usdin, E., Åsberg, M., Bertilsson, L. & Sjöqvist, F. New York, Raven Press.Google Scholar
Maas, J. W. (1984) Relationship between central nervous system noradrenergic function and plasma and urinary concentrations of norepinephrine metabolites In Frontiers in biochemical and pharmacological research in depression, eds. Usdin, E., Åsberg, M., Bertilsson, L. & Sjoqvist, F. New York: Raven Press Google Scholar
Maas, J. W., Hattox, S. E., Greene, N. M. & Landis, D. H. (1979) 3-Methoxy-4-hydroxyphenethyleneglycol production by human brain in vivo. Science, 205, 1025–1027.CrossRefGoogle ScholarPubMed
Martin, P. R., Ebert, M. H., Gordon, E. K., Linnoila, M. & Kopin, I. J. (1984) Effects of Clonidine on central and peripheral catecholamine metabolism. Clinical Pharmacology and Metabolism, 35, 322–327.Google Scholar
Rosenbaum, A. H., Maruta, T., Schatzberg, A. F., Orsulak, P. J., Jiang, N. S., Cole, J. O. & Schildkraut, J. J. (1983) Toward a biochemical classification of depressive disorders, VII: Urinary free Cortisol and urinary MHPG in depression. American Journal of Psychiatry, 140, 314–318.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.