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Symptom severity and cognitive impairment in chronically hospitalised geriatric patients with affective disorders

Published online by Cambridge University Press:  03 January 2018

Philip D. Harvey. Peter Powchik ,
Michael Parrella ,
Leonard White  and
Michael Davidson
Philip D. Harvey. Peter Powchik*
Affiliation:
Department of Psychiatry, Mt Sinai School of Medicine, New York, USA
Michael Parrella
Affiliation:
Department of Psychiatry, Mt Sinai School of Medicine, New York, USA
Leonard White
Affiliation:
Department of Psychiatry, Mt Sinai School of Medicine, New York, USA
Michael Davidson
Affiliation:
Department of Psychiatry, Mt Sinai School of Medicine, New York, USA
*
Dr Philip D. Harvey. Department of Psychiatry, Box 1229, Mt Sinai School of Medicine, New York, NY10029, USA
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Abstract

Background

Affective disorders typically have a better outcome than schizophrenia, although recent evidence suggests that some patients with affective disorder have a relatively poor outcome, with cognitive impairments and persistent symptomatology.

Method

Fifty chronically hospitalised geriatric patients with mood disorders (major depression or bipolar disorder) were compared on the clinical symptoms and aspects of cognitive impairment with 308 geriatric schizophrenic patients who were hospitalised at the same institution. The two samples did not differ in current age or in premorbid education level, but the affective patients had a later age of onset and more females in the sample.

Results

There were no overall differences in cognitive functioning between the groups, although the clinical symptom profiles resembled those seen in better outcome patients.

Conclusions

Cognitive impairment is present in poor-outcome patients with affective disorders as well as schizophrenia, suggesting that cognitive impairments predict poor outcome across psychiatric disorders and not just in schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 170 , Issue 4 , April 1997 , pp. 369 - 374
Copyright
Copyright © 1997 The Royal College of Psychiatrists 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM-III-R). Washington. DC: APA Google Scholar
Breier, A., Schreiber, J. L., Dyer, J., et al (1991) National Institute of Mental Health longitudinal study of schizophrenia: Prognosis and predictors of outcome. Archives of General Psychiatry, 48, 239–246.CrossRefGoogle ScholarPubMed
Crow, T. J. (1990) The continuum of psychosis and its genetic origins: The 65th Maudsley Lecture. British Journal of Psychiatry, 156, 788–797.CrossRefGoogle Scholar
Davidson, M., Harvey, P. D., Powchik, P., et al (1995) Severity of symptoms in geriatric chronically institutionalized schizophrenic patients. American Journal of Psychiatry, 152, 197–207.Google Scholar
Davidson, M., Harvey, P. D., Powchik, P., Welsh, K. A., et al (1996) Cognitive impairment in old-age schizophrenia: a comparative study of schizophrenic patients and patients with Alzheimer's disease. American journal of Psychiatry, 153, 1274–1279.Google Scholar
Devanand, D. P., Sano, M., Tang, M.-X., et al (1996) Depressed mood and the incidence of Alzheimer's disease in the elderly living in the community. Archives of General Psychiatry, 53, 175–182.CrossRefGoogle ScholarPubMed
Folstein, M. F., Folstein, S. E. & McHugh, P K. (1975) Mini-Mental State: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Furukawa, T., Nakazato, H. & Sumita, Y. (1993) Characteristics of chronic outpatients with unipolar depression. Acta Psychiatrica Scandinavica, 88, 273–277.CrossRefGoogle ScholarPubMed
Gold, J. M. & Harvey, P. D. (1993) Cognitive deficits in schizophrenia. Psychiatric Clinics of North America. 16, 295–312.CrossRefGoogle ScholarPubMed
Goldberg, J. F., Harrow, M. & Grossman, L. (1995) Recurrent affective syndromes in bipolar and unipolar mood disorders at follow-up. British Journal of Psychiatry, 166, 382–385.CrossRefGoogle ScholarPubMed
Goldberg, T. E., Gold, J. M., Greenberg, R., et al (1993) Contrasts between patients with affective disorders and patients with schizophrenia on a neuropsychological battery. American Journal of Psychiatry, 150, 1355–1362.Google Scholar
Harvey, P D., Lombardi, J., Kincaid, M. M., et al (1995) Cognitive functioning in chronically hospitalized schizophrenic patients: age-related changes and age disorientation as a predictor of impairment. Schizophrenia Research, 17, 15–24.CrossRefGoogle ScholarPubMed
Kay, S. R. (1991) Positive and Negative Syndromes in Schizophrenia. New York: Brunner/Mazel.Google ScholarPubMed
Lombardi, J., Harvey, P D., White, L., et al (1996) Age disorientation in chronically hospitalized patients with mood disorders. Psychiatry Research, 60, 87–90.CrossRefGoogle ScholarPubMed
McEwen, B. S. & Sapolsky, R. M. (1995) Stress and cognitive function. Current Opinion in Neurobiology, 5, 205–216.CrossRefGoogle ScholarPubMed
McKay, A. P. Tarbuck, A. F., Spapleske, J., et al (1995) Neuropsychological functions in manic-depressive psychosis: evidence of chronic persistent deficits in patients with chronic, severe illness. British Journal of Psychiatry 167, 51–57.CrossRefGoogle ScholarPubMed
Marneros, A., Deister, A. & Rohde, A. (1992) Comparison of the long-term outcome of schizophrenic, affective, and schizoaffective disorders. British Journal of Psychiatry, 161 (suppl 18), 44–51.CrossRefGoogle Scholar
Morris, J. C., Heyman, A., Mohs, R. C., et al(1989) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Neurology, 39, 1159–1165.Google ScholarPubMed
O'Connell, R. A., Mayo, J. A., Flatow, L., et al (1991) Outcome of bipolar disorder on long-term treatment with lithium. British Journal of Psychiatry, 159, 123–129.CrossRefGoogle ScholarPubMed
Vocisano, C., Klein, D. N., Keefe, R. S. E., et al (1996) Demographics, family history, premorbid functioning, developmental characteristics, and course of patients with deteriorated affective disorder. American journal of Psychiatry, 153, 248–253.Google ScholarPubMed
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