Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-22T21:21:30.665Z Has data issue: false hasContentIssue false
  • English
  • Français

Tritiated Etorphine and Naloxone Binding to Opioid Receptors in Caudate Nucleus in Schizophrenia

Published online by Cambridge University Press:  29 January 2018

F. Owen ,
R. C. Bourne ,
M. Poulter ,
T. J. Crow ,
S. J. Paterson  and
H. W. Kosterlitz
F. Owen*
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
R. C. Bourne
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
M. Poulter
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
T. J. Crow
Affiliation:
Division of Psychiatry, Clinical Research Centre, Watford Road, Harrow, Middlesex HA1 3UJ
S. J. Paterson
Affiliation:
Unit for Research of Addictive Drugs, Marischal College, University of Aberdeen, Aberdeen, Scotland
H. W. Kosterlitz
Affiliation:
Unit for Research of Addictive Drugs, Marischal College, University of Aberdeen, Aberdeen, Scotland
*
∗Correspondence.
Get access Rights & Permissions [Opens in a new window]

Summary

Opioid receptor binding sites were assessed in membrane preparations of caudate nucleus from post-mortem brains of controls and of patients with schizophrenia. There was no difference between the two groups in the total specific binding of 3H-etorphine or in its ‘μ’ and (‘δ+χ’) components. Similarly, the binding of 3H-naloxone did not differ between patients and controls. It is concluded that a previous report of reduced opioid receptors in caudate of schizophrenics is unlikely to prove a consistent finding and that the results of the present study offer no support to the claim that there is a general disturbance in opiate mechanisms in schizophrenia.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 146 , Issue 5 , May 1985 , pp. 507 - 509
Copyright
Copyright © 1985 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bennett, J. P., Enna, S. J., Bylund, D. B., Gillin, J. C., Wyatt, R. J. & Snyder, S. H. (1979) Neurotransmitters receptorsin frontal cortex of schizophrenics. Archives of General Psychiatry, 36, 927–934.Google Scholar
Deakin, J. F. W. (1980) Opiates, opioid peptides and their possible relevance to schizophrenia. In The Biochemistry of Schizophrenia and Addiction, (ed. Hemmings, G.). Lancaster: MTP Press.Google Scholar
Feighner, J. P., Robins, S. B., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.Google Scholar
Jacquet, Y. F. & Marks, N. (1976) Endorphins: Profound behavioural effects in rats suggest new aetiological factors in mental illness. Science, 194, 632–634.CrossRefGoogle Scholar
Kosterutz, H. W. & Paterson, S. J. (1981) Tyr-D-Ala-Gly-MePhe-Gly-ol is a selective ligand for the u-opiate binding site. British Journal of Pharmacology, 73, 299P.Google Scholar
Mackay, A. V. P. (1979) Psychiatric implications of endorphin research. British Journal of Psychiatry, 135, 470–473.Google Scholar
Owen, F., Cross, A. J. & Crow, T. J. (1983) Ligand binding studies in brains of schizophrenics. In Cell Surface Receptors, (ed. Strange, P. G.). Chichester: Ellis Horwood.Google Scholar
Owen, F., Cross, A. J. Poulter, M. & Waddington, J. L. (1979) Change in the characteristics of 3H-spiperone binding to rat striatal membranes after acute chlorpromazine administration: effects of buffer washing of membranes. Life Sciences, 25, 385–390.Google Scholar
Owen, F., Crow, T. J., Poulter, M., Cross, A. J., Longden, A. & Riley, G. S. (1978) Increased dopamine-receptor sensitivity in schizophrenia. Lancet, ii, 223–226.Google Scholar
Reisine, T. D., Rossor, M., Spokes, E., Wersen, L. L. & Yamamura, H. I. (1980) Opiate and neuroleptic receptor alterations in human schizophrenic brain tissue. In Receptors for Neurotransmitters and Reptile Hormones, (eds. Papeu, G., Kuhar, M.J. & Enna, S. J.). New York: Raven Press.Google Scholar
Sutherland, E. N., Cori, C. F., Haynes, R. & Olsen, N. S. (1949) Purification of hyperglycemic-glycogenolytic factor from insulin and from gastric mucosa. Journal of Biological Chemistry, 180, 825–837.Google Scholar
Terenius, L., Wahlstrom, A., Lindstrom, L. & Widerlov, E. (1976) Increased csf levels of endorphins in chronic psychosis. Neuroscience Letters, 3, 157–162.CrossRefGoogle ScholarPubMed
Whitaker, P. M., Crow, T. J. & Ferrier, I. N. (1981) Tritiated LSD binding in frontal cortex in schizophrenia. Archives of General Psychiatry, 38, 278–280.Google Scholar
Wing, J. K., Cooper, J. E. & Sartorius, N. (1974) Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.