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Urinary Cyclic AMP in the Switch Process from Depression to Mania

Published online by Cambridge University Press:  29 January 2018

R. P. Hullin ,
J. G. Salway ,
M. N. E. Allsopp ,
Janet D. M. Albano ,
G. Dawn Barnes  and
B. L. Brown
R. P. Hullin
Affiliation:
Regional Metabolic Research Unit, High Royds Hospital
J. G. Salway
Affiliation:
Biochemistry Department, University of Leeds, 9 Hyde Terrace, Leeds, LS2 9LS
M. N. E. Allsopp
Affiliation:
Biochemistry Department, University of Leeds, 9 Hyde Terrace, Leeds, LS2 9LS
Janet D. M. Albano
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
G. Dawn Barnes
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
B. L. Brown
Affiliation:
Institute of Nuclear Medicine, Middlesex Hospital Medical School, London, W1N 7RL
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Extract

Various reports have suggested that the urinary excretion of adenosine cyclic 3'5’ monophosphate (cyclic AMP) is increased in mania and decreased in depression. However, our own serial studies from short-cycle bipolar manic-depressive patients showed no correlation between mood and cyclic AMP excretion (2). Jenner et al. (4) confirmed our findings, except in the case of a patient with a regular 48-hour mood cycle who did show a correlation between his mood changes and changes in cyclic AMP excretion. Paul et al. (5) also reported a general lack of correlation between these variables, but found a transient increase of urinary cyclic AMP during the rapid switch from depression to mania. We have investigated the situation in a bipolar patient who shows such a rapid switch in mood but have been unable to demonstrate any increase in cyclic AMP excretion during the switch period.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 125 , Issue 588 , November 1974 , pp. 457 - 458
Copyright
Copyright © Royal College of Psychiatrists, 1974 

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References

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2 Brown, B. L., Salway, J. G., Albano, J. D. M., Hullin, R. P. & Ekins, R. P. (1972) Urinary excretion of cychc AMP and manic-depressive psychosis. British Journal of Psychiatry, 120, 405–8.CrossRefGoogle Scholar
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4 Jenner, F. A., Sampson, G. A., Thompson, E. A., Somerville, A. R., Beard, N. A. & Smith, A. A. (1972) Manic-depressive psychosis and urinary excretion of cyclic AMP. British Journal of Psychiatry, 121, 236–7.CrossRefGoogle ScholarPubMed
5 Paul, M. I., Gramer, H. & Bunney, W. E. (1971) Urinary adenosine 3′5′ monophosphate in the switch process from depression to mania. Science, 171, 300–303.CrossRefGoogle ScholarPubMed
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