Hostname: page-component-78c5997874-t5tsf Total loading time: 0 Render date: 2024-11-18T04:20:46.678Z Has data issue: false hasContentIssue false
  • English
  • Français

Ancestral Secondary Cases on Paternal and Maternal Sides in Bipolar Affective Illness

Published online by Cambridge University Press:  29 January 2018

G. F. S. Johnson  and
M. M. Leeman
G. F. S. Johnson
Affiliation:
Department of Psychiatry, University of Sydney, New South Sales 2006, Australia
M. M. Leeman
Affiliation:
Department of Psychiatry, University of Sydney, New South Wales 2006, Australia
Get access Rights & Permissions [Opens in a new window]

Summary

An analysis of the distribution of ancestral secondary cases of affective illness in families of patients with bipolar manic-depressive disorder was undertaken. Twenty probands with at least two affectively ill second degree relatives were available for study. Probands with both parents affected were excluded. The distribution of unilateral to bilateral pairs of all affected relatives, both excluding and including parents, of probands showed no significant differences from that expected in polygenic inheritance. However, separation into bipolar family history, positive or negative, showed significant differences from the expected ratio of unilateral to bilateral pairs in a bipolar family history positive group consistent with a single dominant gene inheritance.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 133 , Issue 1 , July 1978 , pp. 68 - 72
Copyright
Copyright © The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Dunner, D., Fleiss, J., Addonizio, C. & Fieve, R. (1976) Assortive mating in primary affective disorder. Biological Psychiatry 11, 1, 43–51.Google Scholar
Gershon, E. S., Dunner, D. L., Sturt, L., Goodwin, F. K. (1973) Assortive mating in affective disorders. Biological Psychiatry, 7, 63–74.Google Scholar
James, N. McI., Chapman, C. J. (1975) A genetic study of bipolar affective disorder. British Journal of Psychiatry, 126, 449–56.Google Scholar
Johnson, G. & Leeman, M. (1977) An analysis of familial factors in bipolar affective illness. Archives of General Psychiatry, 34, 1074–83.Google Scholar
Mendlewicz, J., Fieve, R. R., Rainer, J. D., Cataldo, M. (1973) Affective disorder on paternal and maternal sides: Observations in bipolar patients with and without a family history. British Journal of Psychiatry, 122, 31–4.CrossRefGoogle ScholarPubMed
Mendlewicz, J., Fleiss, J. L., Cataldo, M. & Rainer, J. D. (1975) Accuracy of the family history method in affective illness. Archives of General Psychiatry, 32, 309–14.Google Scholar
Mendlewicz, J., Fieve, R., Stallone, F. & Fleiss, J. (1972) Genetic history as a predictor of lithium response in manic depressive illness. Lancet, March 11, 599–600.Google Scholar
Misra, P. C. & Burns, B. H. (1977) Lithium non-responders in a lithium clinic, Acta Psychiatrica Scandinavia, 55, 32–40.Google Scholar
Perris, C. (1971) Abnormality of paternal and maternal sides: Observation in bipolar (Manic-depressive) and unipolar depressive psychoses. British Journal of Psychiatry, 118, 207–10.CrossRefGoogle ScholarPubMed
Slater, E. (1966) Expectation of abnormality on paternal and maternal sides: A computational model. Journal of Medical Genetics, 3, 159–61.CrossRefGoogle ScholarPubMed
Slater, E. & Tsuang, M. (1968) Abnormality on paternal and maternal sides: Observations in schizophrenia and manic-depression. Journal of Medical Genetics, 5, 197–99.CrossRefGoogle ScholarPubMed
Slater, E. Maxwell, J. & Price, J. S. (1971) Distribution of ancestral secondary cases in bipolar affective disorders. British Journal of Psychiatry, 118, 215–18.Google Scholar
Winokur, G., Clayton, P. J. & Reich, T. (1969) Manic Depressive Illness, St. Louis, Mo.: C. V. Mosby Co.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.