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Evidence for Autosomal Dominant Transmission in Tourette's Syndrome

United Kingdom Cohort Study

Published online by Cambridge University Press:  02 January 2018

V. Eapen ,
D. L. Pauls  and
M. M. Robertson
V. Eapen
Affiliation:
The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, Academic Department of Psychiatry, University College London Medical School, Middlesex Hospital, Mortimer Street, London W1N 8AA
D. L. Pauls
Affiliation:
Yale Child Study Centre, 230 South Frontage Road, PO Box 3333, New Haven, Connecticut 06510-8009, USA
M. M. Robertson*
Affiliation:
The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, Academic Department of Psychiatry, University College London Medical School, Middlesex Hospital, Mortimer Street, London W1N 8AA
*
∗Correspondence
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Abstract

Complex segregation analyses were performed on families ascertained through 40 unselected consecutive patients with Tourette's syndrome to examine the hypothesis that its transmission is consistent with genetic inheritance. Analyses were done using several diagnostic classifications. All results were consistent with an autosomal dominant gene with high penetrance. The penetrances ranged from 0.882 to 1.000 for males and 0.452 to 0.980 for females, depending upon the specific classification scheme incorporated into the analyses.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 162 , Issue 5 , May 1993 , pp. 593 - 596
Copyright
Copyright © Royal College of Psychiatrists, 1993 

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